Fgfbp1 fibroblast growth factor binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgfbp1provided by RGD
Official Full Name: fibroblast growth factor binding protein 1provided by RGD
Primary source: RGD:621211
See related: EnsemblRapid:ENSRNOG00000003095 AllianceGenome:RGD:621211
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable fibroblast growth factor binding activity. Involved in cell-cell signaling. Predicted to be located in cell surface and extracellular region. Orthologous to human FGFBP1 (fibroblast growth factor binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 127.8), Lung (RPKM 123.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (71316171..71319965)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (67103686..67107492)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (71647429..71650359)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FGF-BP is an early response gene after spinal cord injury and that its upregulation in regenerating spinal cord tissue may provide a molecular mechanism for enhancing the initial FGF2-mediated neurotrophic effects occurring after such tissue damage
Title: Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fibroblast growth factor binding	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor-binding protein 1

Names: FGF-BP; FGF-BP1; FGF-binding protein 1; FGFBP-1; growth factor-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022603.2 → NP_072125.2 fibroblast growth factor-binding protein 1 precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q9QY10

UniProtKB/TrEMBL

A6IJN7, G3V6D7

Conserved Domains (1) summary

pfam06473
Location:15 → 233

FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

71316171..71319965

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251079.5 → XP_006251141.1 fibroblast growth factor-binding protein 1 isoform X2

UniProtKB/Swiss-Prot

Q9QY10

Conserved Domains (1) summary

pfam06473
Location:9 → 196

FGF-BP1; FGF binding protein 1 (FGF-BP1)
XM_006251078.5 → XP_006251140.1 fibroblast growth factor-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006251140.1

UniProtKB/Swiss-Prot

Q9QY10

UniProtKB/TrEMBL

A6IJN7, G3V6D7

Related

ENSRNOP00000004128.3, ENSRNOT00000004128.6

Conserved Domains (1) summary

pfam06473
Location:15 → 233

FGF-BP1; FGF binding protein 1 (FGF-BP1)