Prap1 proline-rich acidic protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prap1provided by RGD
Official Full Name: proline-rich acidic protein 1provided by RGD
Primary source: RGD:61876
See related: EnsemblRapid:ENSRNOG00000018446 AllianceGenome:RGD:61876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Upa
Summary: Predicted to enable triglyceride binding activity. Predicted to be involved in several processes, including cellular response to X-ray; positive regulation of lipid transport; and regulation of mitotic cell cycle phase transition. Predicted to be located in endoplasmic reticulum and extracellular region. Orthologous to human PRAP1 (proline rich acidic protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 10.7), Testes (RPKM 10.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (204312723..204316519)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (194883078..194886874)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (212558257..212562053)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables triglyceride binding	ISO Inferred from Sequence Orthology more info
enables triglyceride binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to X-ray	ISO Inferred from Sequence Orthology more info
involved_in cellular response to X-ray	ISS Inferred from Sequence or Structural Similarity more info
involved_in deactivation of mitotic spindle assembly checkpoint	ISO Inferred from Sequence Orthology more info
involved_in deactivation of mitotic spindle assembly checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of intestinal lipid absorption	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intestinal lipid absorption	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of triglyceride transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proline-rich acidic protein 1

Names: uterine-specific proline-rich acidic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.