Gabre gamma-aminobutyric acid type A receptor subunit epsilon [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gabreprovided by RGD
Official Full Name: gamma-aminobutyric acid type A receptor subunit epsilonprovided by RGD
Primary source: RGD:68320
See related: EnsemblRapid:ENSRNOG00000061182 AllianceGenome:RGD:68320
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA-A receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in gamma-aminobutyric acid signaling pathway and response to xenobiotic stimulus. Is active in GABA-ergic synapse and postsynaptic membrane. Orthologous to human GABRE (gamma-aminobutyric acid type A receptor subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 6.1), Uterus (RPKM 4.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq37

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (155102078..155120821, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (150060035..150078773, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (152220180..152237347, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of epsilon-subunit containing GABA ARs.
Title: Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of ε-subunit containing GABA ARs.
Increased epsilon subunit expression may be critical to preserve respiratory function (and life) despite increased neurosteroid levels during pregnancy.
Title: Increased GABA(A) receptor ε-subunit expression on ventral respiratory column neurons protects breathing during pregnancy.
Our findings suggest that various combinations of GABA(A) alpha3-, theta- and epsilon-subunits may be assembled at a regional and developmental level in the brain.
Title: Expression of GABA(A) receptor alpha3-, theta-, and epsilon-subunit mRNAs during rat CNS development and immunolocalization of the epsilon subunit in developing postnatal spinal cord.
We addressed the localization of the GABAA receptor epsilon subunit protein in two identified hypothalamic neuron groups, tuberomamillary and orexinergic, and the related functional properties.
Title: Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
Expression of GABA-A receptors containing the epsilon subunit in neurons of the rat hypothalamus suggests that these receptors are likely to be involved in the GABAergic control of these neurons.
Title: GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA-A receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables GABA-A receptor activity	IEA Inferred from Electronic Annotation more info
enables GABA-A receptor activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables GABA-gated chloride ion channel activity	ISO Inferred from Sequence Orthology more info
enables GABA-gated chloride ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to benzodiazepine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel activity	IEA Inferred from Electronic Annotation more info
enables extracellular ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	TAS Traceable Author Statement more info	PubMed
involved_in gamma-aminobutyric acid signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in inhibitory synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of chloride transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, GABAergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of GABA-A receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GABA-A receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in GABA-ergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of chloride channel complex	IEA Inferred from Electronic Annotation more info
is_active_in dendrite membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-aminobutyric acid receptor subunit epsilon

Names: GABA(A) receptor subunit epsilon; GABAAR subunit epsilon; gamma-aminobutyric acid (GABA) A receptor, epsilon; gamma-aminobutyric acid (GABA-A) receptor, subunit epsilon; gamma-aminobutyric acid A receptor, epsilon; gamma-aminobutyric acid type A receptor epsilon subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023091.1 → NP_075579.1 gamma-aminobutyric acid receptor subunit epsilon precursor

See identical proteins and their annotated locations for NP_075579.1

Status: PROVISIONAL

Source sequence(s)

AF189262

UniProtKB/TrEMBL

A0A0G2KA77, Q9JLE9

Related

ENSRNOP00000075293.2, ENSRNOT00000087138.3

Conserved Domains (3) summary

TIGR00860
Location:557 → 983

LIC; Cation transporter family protein

pfam02931
Location:555 → 760

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:769 → 983

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

155102078..155120821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063280287.1 → XP_063136357.1 gamma-aminobutyric acid receptor subunit epsilon isoform X2
XM_039100028.2 → XP_038955956.1 gamma-aminobutyric acid receptor subunit epsilon isoform X1

Conserved Domains (4) summary

TIGR00860
Location:557 → 957

LIC; Cation transporter family protein

cd03558
Location:679 → 693

LGIC_ECD; Cys-loop [structural motif]

cl28912
Location:579 → 760

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam05887
Location:314 → 367

Trypan_PARP; Procyclic acidic repetitive protein (PARP)
XM_039100030.2 → XP_038955958.1 gamma-aminobutyric acid receptor subunit epsilon isoform X3

Conserved Domains (5) summary

cd03558
Location:679 → 693

LGIC_ECD; Cys-loop [structural motif]

cd03559
Location:763 → 786

LGIC_TM; TM1 helix [structural motif]

cl28912
Location:579 → 760

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

cl38911
Location:763 → 796

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels

pfam05887
Location:314 → 367

Trypan_PARP; Procyclic acidic repetitive protein (PARP)
XM_039100034.2 → XP_038955962.1 gamma-aminobutyric acid receptor subunit epsilon isoform X5

Conserved Domains (2) summary

cl28912
Location:579 → 639

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam05887
Location:314 → 367

Trypan_PARP; Procyclic acidic repetitive protein (PARP)
XM_039100033.2 → XP_038955961.1 gamma-aminobutyric acid receptor subunit epsilon isoform X4

Conserved Domains (2) summary

cl28912
Location:579 → 671

LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

pfam05887
Location:314 → 367

Trypan_PARP; Procyclic acidic repetitive protein (PARP)