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    Xpnpep1 X-prolyl aminopeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170751, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Xpnpep1provided by RGD
    Official Full Name
    X-prolyl aminopeptidase 1provided by RGD
    Primary source
    RGD:621274
    See related
    EnsemblRapid:ENSRNOG00000012084 AllianceGenome:RGD:621274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables aminopeptidase activity. Involved in proteolysis. Located in cytoplasm. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 465.5), Testes (RPKM 217.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Xpnpep1 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (262006761..262057479, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (252001366..252052077, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (273708217..273758247, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134484925 Neighboring gene uncharacterized LOC134484100 Neighboring gene mitochondrial ribosomal protein L2, pseudogene 1 Neighboring gene uncharacterized LOC108349045 Neighboring gene uncharacterized LOC134484107

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats. Hye Khan MA, et al. PLoS One, 2015. PMID 26683993, Free PMC Article
    2. Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis. Chrastina A, et al. J Vasc Res, 2010. PMID 20431301, Free PMC Article
    3. Cloning and functional expression of the cytoplasmic form of rat aminopeptidase P. Czirják G, et al. Biochim Biophys Acta, 1999 Mar 19. PMID 10095056
    4. Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors. Liu G, et al. Pediatr Res, 2007 Jul. PMID 17515839
    5. Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels. Matsui K, et al. J Am Soc Nephrol, 2003 Aug. PMID 12874451

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aminopeptidase P expression is higher in the cerebral arteries of Fawn Hooded Hypertensive rats compared to Brown Norway rats.
      Title: Elevated Aminopeptidase P Attenuates Cerebral Arterial Responses to Bradykinin in Fawn-Hooded Hypertensive Rats.
    2. Aminopeptidase P expressed in endothelial caveolae appears to be readily accessible to circulating antibody rather specifically in lung.
      Title: Lung vascular targeting using antibody to aminopeptidase P: CT-SPECT imaging, biodistribution and pharmacokinetic analysis.
    3. Results describe the organ distribution, developmental change and specific inhibitors of prolidases I and II in the rat.
      Title: Prolidase isoenzymes in the rat: their organ distribution, developmental change and specific inhibitors.
    4. aminopeptidase p and podoplanin are expressed in endothelial cells of blood and lymphatic vessels
      Title: Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: aminopeptidase p and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metalloaminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in bradykinin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of programmed cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    xaa-Pro aminopeptidase 1
    Names
    X-Pro aminopeptidase 1, soluble
    X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
    X-prolyl aminopeptidase 1, soluble
    aminoacylproline aminopeptidase
    cytoplasmic aminopeptidase P
    cytosolic aminopeptidase P
    sAmp
    soluble aminopeptidase P
    NP_001385589.1
    NP_571988.1
    XP_038940400.1
    XP_063128473.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398660.1 → NP_001385589.1  xaa-Pro aminopeptidase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JV31, A0A8L2QGG3, A6JHT6
      Related
      ENSRNOP00000031325.5, ENSRNOT00000033148.5
      Conserved Domains (4) summary
      cd01085
      Location:372 → 594
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:53 → 197
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:600 → 662
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200 → 369
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. NM_131913.3 → NP_571988.1  xaa-Pro aminopeptidase 1 isoform 2

      See identical proteins and their annotated locations for NP_571988.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O54975
      UniProtKB/TrEMBL
      A0A8L2QGG3, A6JHT7
      Related
      ENSRNOP00000102637.1, ENSRNOT00000158489.1
      Conserved Domains (4) summary
      cd01085
      Location:329 → 551
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:10 → 154
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:557 → 619
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:157 → 326
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      262006761..262057479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039084472.2 → XP_038940400.1  xaa-Pro aminopeptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2V2, A0A8L2QGG3
      Related
      ENSRNOP00000079124.1, ENSRNOT00000111011.2
      Conserved Domains (4) summary
      cd01085
      Location:347 → 547
      APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
      pfam01321
      Location:53 → 197
      Creatinase_N; Creatinase/Prolidase N-terminal domain
      pfam16188
      Location:553 → 615
      Peptidase_M24_C; C-terminal region of peptidase_M24
      pfam16189
      Location:200 → 347
      Creatinase_N_2; Creatinase/Prolidase N-terminal domain

    2. XM_063272403.1 → XP_063128473.1  xaa-Pro aminopeptidase 1 isoform X1

      UniProtKB/Swiss-Prot
      O54975
      UniProtKB/TrEMBL
      A0A8L2QGG3, A6JHT7
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O54975.1 GenPept UniProtKB/Swiss-Prot:O54975

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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