Cd244l1 CD244 molecule like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd244l1provided by RGD
Official Full Name: CD244 molecule like 1provided by RGD
Primary source: RGD:68400
See related: EnsemblRapid:ENSRNOG00000068754 AllianceGenome:RGD:68400
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: 2B4; Nmrk; Cd244
Summary: Predicted to enable MHC class I protein binding activity. Predicted to be involved in natural killer cell activation involved in immune response. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 89.0), Lung (RPKM 23.6) and 5 other tissues See more
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Genomic context

Location:: 13q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86547250..86569026)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84018887..84036612)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89959091..89995993)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2B4 adopts an immunoglobulin variable (V) domain fold, like that of domain 1 of CD2 and CD4 antigens, but with several unique structural and dynamic features related to ligand recognition and receptor function.
Title: NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.
CD48 is a CD2 and CD244 (2B4)-binding protein
Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in natural killer cell activation involved in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: natural killer cell receptor 2B4

Names: CD244 natural killer cell receptor 2B4; Cd244 molecule, natural killer cell receptor 2B4; NK cell type I receptor protein 2B4; NKR2B4; non-MHC restricted killing associated; transmembrane NK cell receptor 2B4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022259.2 → NP_071595.2 natural killer cell receptor 2B4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q9JLM2, Q9JLM3

UniProtKB/TrEMBL

F1LME3

Related

ENSRNOP00000100801.1, ENSRNOT00000152303.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86547250..86569026

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272572.1 → XP_063128642.1 natural killer cell receptor 2B4 isoform X1
XM_063272573.1 → XP_063128643.1 natural killer cell receptor 2B4 isoform X1
XM_063272574.1 → XP_063128644.1 natural killer cell receptor 2B4 isoform X2
XM_039091060.2 → XP_038946988.1 natural killer cell receptor 2B4 isoform X2

Conserved Domains (2) summary

pfam11465
Location:22 → 128

Receptor_2B4; Natural killer cell receptor 2B4

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]
XM_039091061.2 → XP_038946989.1 natural killer cell receptor 2B4 isoform X4

Conserved Domains (2) summary

pfam11465
Location:22 → 128

Receptor_2B4; Natural killer cell receptor 2B4

cd00096
Location:25 → 27

Ig; Ig strand A [structural motif]
XM_063272575.1 → XP_063128645.1 natural killer cell receptor 2B4 isoform X3