Cacna1g calcium voltage-gated channel subunit alpha1 G [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna1gprovided by RGD
Official Full Name: calcium voltage-gated channel subunit alpha1 Gprovided by RGD
Primary source: RGD:68942
See related: EnsemblRapid:ENSRNOG00000060528 AllianceGenome:RGD:68942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables low voltage-gated calcium channel activity. Involved in several processes, including artery smooth muscle contraction; calcium ion transport; and cellular response to dexamethasone stimulus. Located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in cerebellar ataxia type 42. Orthologous to human CACNA1G (calcium voltage-gated channel subunit alpha1 G). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 56.3), Heart (RPKM 53.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (79851886..79919926, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79354998..79422960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82129071..82197828, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CaMK4 is a downstream effector of the alpha1G T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells.
Title: CaMK4 is a downstream effector of the α(1G) T-type calcium channel to determine the angiogenic potential of pulmonary microvascular endothelial cells.
Recombinant adenovirus encoding enhanced green fluorescent protein-CaV3.1 subunit (Ad-EGFP-CaV3.1) efficiently transduced rat and human islets as well as dispersed islet cells. Ad-EGFP-CaV3.1 transduction reduced phosphorylated FoxO1 in the cytoplasm of rat INS-1E cells, elevated FoxO1 nuclear retention, and decreased syntaxin 1A, SNAP-25, and synaptotagmin III.
Title: Enhanced expression of β cell Ca(V)3.1 channels impairs insulin release and glucose homeostasis.
The present work demonstrated that miR-137 and its target T-type CaV 3.1 channel modulate the dedifferentiation and proliferation of rat cerebrovascular smooth muscle cells under simulated microgravity by regulating calcineurin/NFATc3 pathway.
Title: miR-137 and its target T-type Ca(V) 3.1 channel modulate dedifferentiation and proliferation of cerebrovascular smooth muscle cells in simulated microgravity rats by regulating calcineurin/NFAT pathway.
Results confirm the idea that T-channels critically support rebound burst firing following periods of membrane hyperpolarization, similar to those that occur during inhibitory synaptic potentials in the ventral tegmental area. Behavioral results indicate that deletion of CaV3.1 channels disrupts the hyperlocomotion.
Title: Ca(V)3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons.
Results show that the decrease in Cav3.1 channel expression and Ca2+ current component that they carry in thalamocortical relay neurons serves as a protective measure against early onset of spike-wave discharges and absence seizures
Title: Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy.
Results suggest that T-type Ca channels Cav3.1, Cav3.2 and Cav3.3 are potential therapeutic targets for the treatment of spinal nerve ligation-induced neuropathic pain.
Title: Upregulation of T-type Ca2+ channels in primary sensory neurons in spinal nerve injury.
Inhibition of Cav3.1 wild type by Ni(2+) conformed to two sites binding.
Title: Complex modulation of Ca(v)3.1 T-type calcium channel by nickel.
L- and T-type Ca(2+) channels are expressed in cerebral arterial smooth muscle and both conductances contribute to myogenic tone.
Title: Identification of L- and T-type Ca2+ channels in rat cerebral arteries: role in myogenic tone development.
T-type Ca(2)+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes.
Title: T-type Ca²+ signalling regulates aldosterone-induced CREB activation and cell death through PP2A activation in neonatal cardiomyocytes.
Cav3.1 T-type channels interact with divalent calcium ion-dependent steps of the mitogenic signaling cascade as a central component of vascular remodeling in disease.
Title: Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated pulmonary artery smooth muscle cells.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142184 (e-PCR)
- UniSTS:231434

D10Wox53 (e-PCR)
- UniSTS:518698

CACNA1G-1 (e-PCR)
- UniSTS:510336

BE098192 (e-PCR)
- UniSTS:245188

RH130173 (e-PCR)
- UniSTS:213460

RH137526 (e-PCR)
- UniSTS:219614

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables low voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables low voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables low voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables low voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	IEA Inferred from Electronic Annotation more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated calcium channel activity involved in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
enables voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in AV node cell to bundle of His cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in SA node cell to atrial cardiac muscle cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in action potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within action potential	ISO Inferred from Sequence Orthology more info
involved_in artery smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion import	IEA Inferred from Electronic Annotation more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell action potential involved in contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during AV node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during SA node cell action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of atrial cardiac muscle cell membrane depolarization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in response to nickel cation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to nickel cation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IC Inferred by Curator more info	PubMed
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-dependent T-type calcium channel subunit alpha-1G

Names: calcium channel, voltage-dependent, T type, alpha 1G subunit; voltage-gated calcium channel subunit alpha Cav3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308302.2 → NP_001295231.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I5ZQG3, Q9WUB8

Conserved Domains (2) summary

PHA03307
Location:2019 → 2270

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
NM_031601.5 → NP_113789.4 voltage-dependent T-type calcium channel subunit alpha-1G isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks two in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O54898, Q548R1

UniProtKB/TrEMBL

A6HI48

Related

ENSRNOP00000071940.3, ENSRNOT00000081307.3

Conserved Domains (2) summary

PHA03307
Location:1985 → 2236

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

79851886..79919926 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597189.3 → XP_017452678.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X5

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:2041 → 2292

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein
XM_008767988.4 → XP_008766210.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X4

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:2078 → 2329

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein
XM_008767986.4 → XP_008766208.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X2

UniProtKB/TrEMBL

A0A8I5ZQG3, A0A8I5ZVK1

Related

ENSRNOP00000082604.1, ENSRNOT00000115912.2

Conserved Domains (2) summary

PHA03307
Location:2112 → 2363

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
XM_008767987.4 → XP_008766209.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X3

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:2101 → 2352

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
XM_008767985.4 → XP_008766207.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X1

UniProtKB/TrEMBL

A0A8I5ZQG3

Conserved Domains (2) summary

PHA03307
Location:2119 → 2370

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
XM_008768000.4 → XP_008766222.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X11

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:1979 → 2230

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:726 → 959

Ion_trans; Ion transport protein
XM_008768001.4 → XP_008766223.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X12

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:1978 → 2229

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein
XM_008767999.4 → XP_008766221.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X10

UniProtKB/Swiss-Prot

O54898, Q548R1

Related

ENSRNOP00000091253.2, ENSRNOT00000106257.2

Conserved Domains (2) summary

PHA03307
Location:1996 → 2247

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein
XM_008767997.4 → XP_008766219.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X8

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:2003 → 2254

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 976

Ion_trans; Ion transport protein
XM_008767998.4 → XP_008766220.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X9

UniProtKB/Swiss-Prot

O54898, Q548R1

Conserved Domains (2) summary

PHA03307
Location:2001 → 2252

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
XM_008767996.4 → XP_008766218.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X7

UniProtKB/Swiss-Prot

O54898, Q548R1

UniProtKB/TrEMBL

A0A0G2K1Q5

Related

ENSRNOP00000104356.1, ENSRNOT00000138373.1

Conserved Domains (2) summary

PHA03307
Location:2008 → 2259

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein
XM_008767994.4 → XP_008766216.2 voltage-dependent T-type calcium channel subunit alpha-1G isoform X6

UniProtKB/TrEMBL

A0A0G2K209, A0A8I5ZQG3

Related

ENSRNOP00000072061.2, ENSRNOT00000092024.3

Conserved Domains (2) summary

PHA03307
Location:2026 → 2277

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:743 → 969

Ion_trans; Ion transport protein