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    Idh3g isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25179, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Idh3gprovided by RGD
    Official Full Name
    isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gammaprovided by RGD
    Primary source
    RGD:2863
    See related
    EnsemblRapid:ENSRNOG00000055572 AllianceGenome:RGD:2863
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    IDH
    Summary
    Predicted to enable enzyme activator activity; isocitrate dehydrogenase (NAD+) activity; and magnesium ion binding activity. Predicted to be involved in isocitrate metabolic process and tricarboxylic acid cycle. Predicted to be located in nucleolus. Predicted to be part of isocitrate dehydrogenase complex (NAD+). Predicted to be active in mitochondrion. Orthologous to human IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 1388.9), Muscle (RPKM 863.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Idh3g in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156666573..156675482, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151515244..151524175, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156999803..157008735)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene plexin B3 Neighboring gene SRSF protein kinase 3 Neighboring gene signal sequence receptor subunit 4 Neighboring gene PDZ domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and expression of rat interferon beta gene and growth-inhibitory effect of its expression on rat glioma cells. Yokoyama S, et al. Biochem Biophys Res Commun, 1997 Mar 27. PMID 9126338
    2. Molecular cloning and deduced amino acid sequences of the gamma-subunits of rat and monkey NAD(+)-isocitrate dehydrogenases. Nichols BJ, et al. Biochem J, 1993 Oct 15. PMID 8240232, Free PMC Article
    3. Cysteinyl peptide labeled by 3-bromo-2-ketoglutarate in the active site of pig heart NAD+-dependent isocitrate dehydrogenase. Saha A, et al. Biochemistry, 1989 Oct 17. PMID 2605193
    4. Molecular mechanism of the allosteric regulation of the αγ heterodimer of human NAD-dependent isocitrate dehydrogenase. Ma T, et al. Sci Rep, 2017 Jan 18. PMID 28098230, Free PMC Article
    5. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Brenner V, et al. Genomics, 1997 Aug 15. PMID 9286695

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94551

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables isocitrate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isocitrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isocitrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in isocitrate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tricarboxylic acid cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tricarboxylic acid cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of isocitrate dehydrogenase complex (NAD+) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of isocitrate dehydrogenase complex (NAD+) ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial
    Names
    NAD (H)-specific isocitrate dehydrogenase gamma subunit
    NAD(+)-specific ICDH subunit gamma
    NAD+-isocitrate dehydrogenase gamma subunit
    isocitrate dehydrogenase (NAD(+)) 3 gamma
    isocitrate dehydrogenase 3 (NAD), gamma
    isocitrate dehydrogenase 3, gamma
    isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
    isocitric dehydrogenase subunit gamma
    NP_113739.1
    XP_006229614.1
    XP_006229615.1
    XP_006229616.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431553.1 → NP_001418482.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P41565, P70577
      UniProtKB/TrEMBL
      A0A0G2K4Q0

    2. NM_031551.2 → NP_113739.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform 2 precursor

      See identical proteins and their annotated locations for NP_113739.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      P41565, P70577
      UniProtKB/TrEMBL
      Q5XIJ3
      Related
      ENSRNOP00000073128.3, ENSRNOT00000081819.3
      Conserved Domains (1) summary
      TIGR00175
      Location:52 → 383
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156666573..156675482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229552.5 → XP_006229614.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X1

      Related
      ENSRNOP00000096912.2, ENSRNOT00000113059.2
      Conserved Domains (1) summary
      TIGR00175
      Location:48 → 379
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    2. XM_006229553.5 → XP_006229615.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006229615.1

      UniProtKB/TrEMBL
      A6KRV1, A6KRV3
      Conserved Domains (1) summary
      TIGR00175
      Location:1 → 325
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type

    3. XM_006229554.4 → XP_006229616.1  isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial isoform X2

      See identical proteins and their annotated locations for XP_006229616.1

      UniProtKB/TrEMBL
      A6KRV1, A6KRV3
      Related
      ENSRNOP00000085780.1, ENSRNOT00000113588.2
      Conserved Domains (1) summary
      TIGR00175
      Location:1 → 325
      mito_nad_idh; isocitrate dehydrogenase, NAD-dependent, mitochondrial type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P41565.2 GenPept UniProtKB/Swiss-Prot:P41565

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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