Ncoa6 nuclear receptor coactivator 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ncoa6provided by RGD
Official Full Name: nuclear receptor coactivator 6provided by RGD
Primary source: RGD:620111
See related: EnsemblRapid:ENSRNOG00000018288 AllianceGenome:RGD:620111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NRC; Aib3; PRIP; Trbp; RAP250
Summary: Enables several functions, including nuclear receptor binding activity; nuclear receptor coactivator activity; and peroxisome proliferator activated receptor binding activity. Involved in ovarian follicle development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of transcription by RNA polymerase II. Part of protein-containing complex. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in breast cancer; colon cancer; and lung cancer. Orthologous to human NCOA6 (nuclear receptor coactivator 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 82.1), Kidney (RPKM 75.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41-q42

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (164351062..164422079, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (143890896..143961916, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (150919317..150990391, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the processing of a subset of neuronal precursor microRNAs, among them the dendritically localized pre-miR16, was impaired. Decreased production of miR-16-5p, which targeted the BDNF mRNA itself, was rescued by expression of a membrane-targeted TRBP Moreover, miR-16-5p or membrane-targeted TRBP expression blocked BDNF-induced dendritogenesis, demonstrating the importance of neuronal TRBP dynamics
Title: The dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development.
PRIP inhibits regulated exocytosis through the interaction of its C2 domain with syntaxin 1 and SNAP-25, potentially competing with accessory proteins such as synaptotagmin I and by directly inhibiting trans-SNARE complex formation
Title: PRIP (phospholipase C-related but catalytically inactive protein) inhibits exocytosis by direct interactions with syntaxin 1 and SNAP-25 through its C2 domain.
PRIP is involved in the regulation of the phospho-states of SNAP-25 by modulating the activity of PP1, thus regulating exocytosis.
Title: Phospholipase C-related but catalytically inactive protein (PRIP) modulates synaptosomal-associated protein 25 (SNAP-25) phosphorylation and exocytosis.
Primary islets ectopically expressing dominant-negative fragments of ASC-2 exhibited decreased insulin secretion.
Title: Regulation of insulin secretion and beta-cell mass by activating signal cointegrator 2.
may play potential roles in follicular development and ovulation
Title: Expression and localization of RAP250 mRNA in rat ovary: possible implications in follicular development and ovulation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin-protein adaptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables nuclear retinoic acid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear retinoid X receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear thyroid hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables nuclear thyroid hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear vitamin D receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables peroxisome proliferator activated receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription initiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within labyrinthine layer blood vessel development	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myeloid cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ovarian follicle development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptide secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of MLL3/4 complex	IEA Inferred from Electronic Annotation more info
part_of MLL3/4 complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor coactivator 6

Names: PPAR-interacting protein; activating signal cointegrator 2; amplified in breast cancer protein 3; cancer-amplified transcriptional coactivator ASC-2; nuclear receptor-activating protein, 250 kDa; peroxisome proliferator-activated receptor-interacting protein; thyroid hormone receptor binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276714.2 → NP_001263643.1 nuclear receptor coactivator 6 isoform 2

See identical proteins and their annotated locations for NP_001263643.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU2, A6KI36, G3V8C9

Conserved Domains (2) summary

pfam09606
Location:388 → 799

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
NM_001429659.1 → NP_001416588.1 nuclear receptor coactivator 6 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6ARE2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

164351062..164422079 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282997.1 → XP_063139067.1 nuclear receptor coactivator 6 isoform X8
XM_039104105.2 → XP_038960033.1 nuclear receptor coactivator 6 isoform X4

UniProtKB/TrEMBL

A0A8I6AHU2

Conserved Domains (4) summary

PHA03247
Location:166 → 474

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:1482 → 1801

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09606
Location:444 → 842

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_063282996.1 → XP_063139066.1 nuclear receptor coactivator 6 isoform X7
XM_039104104.2 → XP_038960032.1 nuclear receptor coactivator 6 isoform X3

UniProtKB/TrEMBL

A0A8I6AHU2

Conserved Domains (4) summary

PHA03247
Location:166 → 474

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:1483 → 1802

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09606
Location:427 → 843

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_039104107.2 → XP_038960035.1 nuclear receptor coactivator 6 isoform X6

Conserved Domains (3) summary

PHA03247
Location:166 → 540

PHA03247; large tegument protein UL36; Provisional

pfam09606
Location:461 → 854

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_039104106.2 → XP_038960034.1 nuclear receptor coactivator 6 isoform X5

Related

ENSRNOP00000097352.1, ENSRNOT00000118396.2

Conserved Domains (3) summary

PHA03247
Location:166 → 540

PHA03247; large tegument protein UL36; Provisional

pfam09606
Location:461 → 854

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_039104103.2 → XP_038960031.1 nuclear receptor coactivator 6 isoform X2

UniProtKB/TrEMBL

A0A8I6AHU2

Related

ENSRNOP00000093567.2, ENSRNOT00000114206.2

Conserved Domains (4) summary

PHA03247
Location:166 → 539

PHA03247; large tegument protein UL36; Provisional

pfam05109
Location:1494 → 1813

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

pfam09606
Location:461 → 854

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_006235296.5 → XP_006235358.1 nuclear receptor coactivator 6 isoform X1

Conserved Domains (2) summary

pfam09606
Location:388 → 799

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region
XM_008762295.4 → XP_008760517.1 nuclear receptor coactivator 6 isoform X1

See identical proteins and their annotated locations for XP_008760517.1

UniProtKB/TrEMBL

A0A8I6AHU2, A6KI36, G3V8C9

Related

ENSRNOP00000024714.6, ENSRNOT00000024714.9

Conserved Domains (2) summary

pfam09606
Location:388 → 799

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

pfam13820
Location:48 → 190

Nucleic_acid_bd; Putative nucleic acid-binding region