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    Trim27 tripartite motif-containing 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291171, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Trim27provided by RGD
    Official Full Name
    tripartite motif-containing 27provided by RGD
    Primary source
    RGD:1310105
    See related
    EnsemblRapid:ENSRNOG00000055917 AllianceGenome:RGD:1310105
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rfp1
    Summary
    Predicted to enable identical protein binding activity; transcription coactivator activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; defense response to symbiont; and regulation of gene expression. Predicted to act upstream of or within negative regulation of gene expression, epigenetic and positive regulation of actin nucleation. Predicted to be located in endosome and nucleus. Predicted to be part of retromer complex. Predicted to be active in cytoplasm. Orthologous to human TRIM27 (tripartite motif containing 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 189.8), Testes (RPKM 171.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Trim27 in Genome Data Viewer
    Location:
    17q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (48233999..48246348, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (43538282..43550633, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (45613863..45626212, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene transfer RNA arginine (anticodon CCG) 3 Neighboring gene transfer RNA leucine (anticodon CAA) 2 Neighboring gene uncharacterized LOC134482717 Neighboring gene transfer RNA glutamine (anticodon CUG) 10 Neighboring gene transfer RNA leucine (anticodon CAA) 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways. Chen Y, et al. Bioengineered, 2022 Apr. PMID 35311628, Free PMC Article
    2. Mapping of the Olf89 and Rfp genes to the rat genome: comparison with the mouse and human and new insights into the evolution of the rodent genome. Szpirer C, et al. Cytogenet Cell Genet, 1997. PMID 9371408
    3. The Ret finger protein induces apoptosis via its RING finger-B box-coiled-coil motif. Dho SH, et al. J Biol Chem, 2003 Aug 22. PMID 12807881
    4. Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease. Liu Y, et al. Brain Res, 2014 Nov 7. PMID 25223908
    5. Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis. Wang C, et al. J Chem Neuroanat, 2023 Apr. PMID 36796734

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.
      Title: Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy through inhibiting inflammation and microglia cell activation by regulating STAT3/HMGB1 axis.
    2. Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways.
      Title: Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR signal pathways.
    3. Data showed that Trim27 deficiency decreases apoptosis and protects dopaminergic neurons in MPTP poisoning, suggesting that Trim27 may be an effective potential target during the treatment of Parkinson's disease
      Title: Deficiency of Trim27 protects dopaminergic neurons from apoptosis in the neurotoxin model of Parkinson's disease.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189472

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of adaptive immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-2 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of viral transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in suppression of viral release by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of retromer complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein RFP
    Names
    ret finger protein 1
    tripartite motif protein 27
    NP_001128446.1
    XP_038951445.1
    XP_038951446.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134974.1 → NP_001128446.1  zinc finger protein RFP

      See identical proteins and their annotated locations for NP_001128446.1

      Status: PROVISIONAL

      Source sequence(s)
      BC169072
      UniProtKB/TrEMBL
      A0A0G2K8V4, A0A8I6A5I2, B5DFI5
      Related
      ENSRNOP00000074750.1, ENSRNOT00000077363.3
      Conserved Domains (4) summary
      COG1196
      Location:140 → 312
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15814
      Location:315 → 491
      SPRY_PRY_TRIM27; PRY/SPRY domain in tripartite motif-containing protein 27 (TRIM27), also known as RING finger protein 76 (RNF76)
      cd16594
      Location:13 → 57
      RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins
      cd19762
      Location:94 → 137
      Bbox2_TRIM7-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins TRIM7, TRIM27 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      48233999..48246348 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095517.2 → XP_038951445.1  zinc finger protein RFP isoform X1

      Conserved Domains (1) summary
      cl02614
      Location:139 → 315
      SPRY; SPRY domain

    2. XM_039095518.2 → XP_038951446.1  zinc finger protein RFP isoform X1

      Conserved Domains (1) summary
      cl02614
      Location:139 → 315
      SPRY; SPRY domain

    RNA

    1. XR_005495255.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106115.1: Suppressed sequence

      Description
      NM_001106115.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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