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    Krt6c keratin 6c [ Rattus norvegicus (Norway rat) ]

    Gene ID: 683313, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt6cprovided by RGD
    Official Full Name
    keratin 6cprovided by RGD
    Primary source
    RGD:1588056
    See related
    EnsemblRapid:ENSRNOG00000070470 AllianceGenome:RGD:1588056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CK-6A; Krt6a
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament organization; keratinization; and wound healing. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6A (keratin 6A); KRT6B (keratin 6B); and KRT6C (keratin 6C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Krt6c in Genome Data Viewer
    Location:
    7q36
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (134678316..134682753, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (132799608..132804045, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479788 Neighboring gene keratin, type II cytoskeletal 6A-like Neighboring gene keratin, type II cytoskeletal 6A-like Neighboring gene keratin 6A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans. Paine ML, et al. Cancer Res, 1992 Dec 1. PMID 1384967
    2. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in wound healing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type II cytoskeletal 6A
    Names
    K6a keratin
    cytokeratin-6A
    keratin K6
    keratin, type II cytoskeletal 5
    keratin, type II cytoskeletal 5-like
    type-II keratin Kb6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101007.1 → NP_001094477.1  keratin, type II cytoskeletal 6A

      See identical proteins and their annotated locations for NP_001094477.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099121
      UniProtKB/Swiss-Prot
      Q4FZU2
      Related
      ENSRNOP00000087976.1, ENSRNOT00000102479.2
      Conserved Domains (3) summary
      pfam00038
      Location:151 → 464
      Filament; Intermediate filament protein
      pfam16208
      Location:15 → 148
      Keratin_2_head; Keratin type II head
      cl01888
      Location:377 → 437
      DUF883; Bacterial protein of unknown function (DUF883)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      134678316..134682753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZU2.1 GenPept UniProtKB/Swiss-Prot:Q4FZU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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