Abhd16a abhydrolase domain containing 16A, phospholipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd16aprovided by RGD
Official Full Name: abhydrolase domain containing 16A, phospholipaseprovided by RGD
Primary source: RGD:1303164
See related: EnsemblRapid:ENSRNOG00000056637 AllianceGenome:RGD:1303164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bat5; NG26
Summary: Predicted to enable monoacylglycerol lipase activity and phospholipase activity. Predicted to be involved in monoacylglycerol catabolic process; phosphatidylserine catabolic process; and prostaglandin catabolic process. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 86. Orthologous to human ABHD16A (abhydrolase domain containing 16A, phospholipase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 256.3), Muscle (RPKM 203.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (3723756..3738617, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (3719089..3733952, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5080070..5094935)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BAT5 is a genuine lipase with preference for long-chain unsaturated monoacylglycerols, and could in this capacity regulate glycerolipid metabolism in vivo as well.
Title: Biochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A).

Submit: New GeneRIF Correction

General gene information

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Markers

D20Yum51 (e-PCR)
- UniSTS:526106

RH138896 (e-PCR)
- UniSTS:220983

AI326074 (e-PCR)
- UniSTS:160653

RH133704 (e-PCR)
- UniSTS:216987

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoacylglycerol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in monoacylglycerol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoacylglycerol catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylserine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin catabolic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylserine lipase ABHD16A

Names: HLA-B associated transcript 5; HLA-B-associated transcript 5 homolog; abhydrolase domain-containing protein 16A; alpha/beta hydrolase domain-containing protein 16A; monoacylglycerol lipase ABHD16A; protein ABHD16A; protein BAT5

NP_997696.1

EC 3.1.1.23

XP_038954730.1

EC 3.1.1.23

XP_063135278.1

EC 3.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212531.2 → NP_997696.1 phosphatidylserine lipase ABHD16A

See identical proteins and their annotated locations for NP_997696.1

Status: VALIDATED

Source sequence(s)

BC091227, CK653480

UniProtKB/Swiss-Prot

Q6MG55

UniProtKB/TrEMBL

A0A0G2K4N8, A6KTT1

Related

ENSRNOP00000098134.2, ENSRNOT00000120470.2

Conserved Domains (1) summary

pfam00561
Location:280 → 408

Abhydrolase_1; alpha/beta hydrolase fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

3723756..3738617 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098802.2 → XP_038954730.1 phosphatidylserine lipase ABHD16A isoform X1

UniProtKB/TrEMBL

A0A0G2K0X5, A0A0G2K4N8, A6KTT5

Related

ENSRNOP00000071617.2, ENSRNOT00000077082.4

Conserved Domains (1) summary

cl21494
Location:237 → 365

Abhydrolase; alpha/beta hydrolases
XM_063279208.1 → XP_063135278.1 phosphatidylserine lipase ABHD16A isoform X2