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    Fastk Fas-activated serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fastkprovided by RGD
    Official Full Name
    Fas-activated serine/threonine kinaseprovided by RGD
    Primary source
    RGD:1311601
    See related
    EnsemblRapid:ENSRNOG00000011667 AllianceGenome:RGD:1311601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of gene expression. Predicted to be located in mitochondrion and nuclear speck. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTK (Fas activated serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 252.5), Muscle (RPKM 194.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fastk in Genome Data Viewer
    Location:
    4q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (11624697..11628769)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (10732273..10736332)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (7260521..7264590)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene uncharacterized LOC134486542 Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene solute carrier family 4 member 2 Neighboring gene cyclin-dependent kinase 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. Simarro M, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592127, Free PMC Article
    2. Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis. Tian Q, et al. J Exp Med, 1995 Sep 1. PMID 7544399, Free PMC Article
    3. Fas-activated serine/threonine kinase (FAST K) synergizes with TIA-1/TIAR proteins to regulate Fas alternative splicing. Izquierdo JM, et al. J Biol Chem, 2007 Jan 19. PMID 17135269
    4. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fas-activated serine/threonine kinase
    NP_001358218.1
    XP_006235956.1
    XP_006235957.1
    XP_017448427.1
    XP_038963148.1
    XP_038963151.1
    XP_063141764.1
    XP_063141765.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371289.1 → NP_001358218.1  fas-activated serine/threonine kinase

      Status: VALIDATED

      Source sequence(s)
      BC083715, JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6A5X4
      Related
      ENSRNOP00000086402.1, ENSRNOT00000093879.2
      Conserved Domains (3) summary
      smart00952
      Location:480 → 532
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:274 → 339
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:352 → 439
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      11624697..11628769
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107220.2 → XP_038963148.1  fas-activated serine/threonine kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5X4
      Related
      ENSRNOP00000106571.1, ENSRNOT00000122749.1
      Conserved Domains (3) summary
      smart00952
      Location:452 → 504
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:246 → 311
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:324 → 411
      FAST_2; FAST kinase-like protein, subdomain 2

    2. XM_063285695.1 → XP_063141765.1  fas-activated serine/threonine kinase isoform X4

    3. XM_006235894.5 → XP_006235956.1  fas-activated serine/threonine kinase isoform X2

      See identical proteins and their annotated locations for XP_006235956.1

      UniProtKB/TrEMBL
      A0A8I6A5X4, A0A8I6AQA7, A6K549
      Related
      ENSRNOP00000096270.2, ENSRNOT00000107208.2
      Conserved Domains (3) summary
      smart00952
      Location:446 → 498
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:240 → 305
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:318 → 405
      FAST_2; FAST kinase-like protein, subdomain 2

    4. XM_006235895.4 → XP_006235957.1  fas-activated serine/threonine kinase isoform X2

      See identical proteins and their annotated locations for XP_006235957.1

      UniProtKB/TrEMBL
      A0A8I6A5X4, A0A8I6AQA7, A6K549
      Conserved Domains (3) summary
      smart00952
      Location:446 → 498
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:240 → 305
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:318 → 405
      FAST_2; FAST kinase-like protein, subdomain 2

    5. XM_017592938.3 → XP_017448427.1  fas-activated serine/threonine kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5X4, A0A8I6AQA7, A6K549
      Conserved Domains (3) summary
      smart00952
      Location:446 → 498
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:240 → 305
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:318 → 405
      FAST_2; FAST kinase-like protein, subdomain 2

    6. XM_063285694.1 → XP_063141764.1  fas-activated serine/threonine kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5X4

    7. XM_039107223.2 → XP_038963151.1  fas-activated serine/threonine kinase isoform X5

      Conserved Domains (3) summary
      smart00952
      Location:245 → 297
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:39 → 104
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:117 → 204
      FAST_2; FAST kinase-like protein, subdomain 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001011967.1: Suppressed sequence

      Description
      NM_001011967.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: fastk (GeneID:564534).
    Nucleotide Protein Strain
    Heading Accession and Version

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