Pqbp1 polyglutamine binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pqbp1provided by RGD
Official Full Name: polyglutamine binding protein 1provided by RGD
Primary source: RGD:1549750
See related: EnsemblRapid:ENSRNOG00000007766 AllianceGenome:RGD:1549750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GTPase binding activity. Involved in positive regulation of non-motile cilium assembly. Located in centrosome and ciliary base. Human ortholog(s) of this gene implicated in Renpenning syndrome. Orthologous to human PQBP1 (polyglutamine binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 256.0), Thymus (RPKM 206.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (17275445..17280018)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (14603516..14608091)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (15448570..15453130)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in alternative mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of dendrite morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary base	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in neuronal ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polyglutamine-binding protein 1

Names: PQBP-1; polyglutamine tract-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013957.3 → NP_001013979.2 polyglutamine-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705

Related

ENSRNOP00000010536.3, ENSRNOT00000010536.7

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
NM_001434005.1 → NP_001420934.1 polyglutamine-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705
NM_001434006.1 → NP_001420935.1 polyglutamine-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705
NM_001434007.1 → NP_001420936.1 polyglutamine-binding protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

17275445..17280018

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256708.5 → XP_006256770.1 polyglutamine-binding protein 1 isoform X1

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_006256707.4 → XP_006256769.1 polyglutamine-binding protein 1 isoform X1

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_063279921.1 → XP_063135991.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705
XM_017601995.3 → XP_017457484.1 polyglutamine-binding protein 1 isoform X1

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_063279922.1 → XP_063135992.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705
XM_017601996.3 → XP_017457485.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_039099631.2 → XP_038955559.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_017601994.3 → XP_017457483.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705

Conserved Domains (1) summary

smart00456
Location:47 → 78

WW; Domain with 2 conserved Trp (W) residues
XM_063279920.1 → XP_063135990.1 polyglutamine-binding protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6PCT5

UniProtKB/TrEMBL

A6KP66, G3V705