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    Cyb561a3 cytochrome b561 family, member A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyb561a3provided by RGD
    Official Full Name
    cytochrome b561 family, member A3provided by RGD
    Primary source
    RGD:1304670
    See related
    EnsemblRapid:ENSRNOG00000020702 AllianceGenome:RGD:1304670
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cybasc3; RGD1304670
    Summary
    Predicted to enable transmembrane ascorbate ferrireductase activity. Predicted to be involved in intracellular iron ion homeostasis. Predicted to be located in late endosome membrane; lysosome; and nucleolus. Predicted to be active in lysosomal membrane. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 445.5), Thymus (RPKM 73.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyb561a3 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216641108..216662495)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207216185..207237575)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226620933..226642246)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene ribosomal protein L31, pseudogene 6 Neighboring gene transmembrane protein 138 Neighboring gene triokinase and FMN cyclase Neighboring gene damage-specific DNA binding protein 1 Neighboring gene von Willebrand factor C and EGF domains Neighboring gene pepsinogen A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An ascorbate-reducible cytochrome b561 is localized in macrophage lysosomes. Zhang DL, et al. Biochim Biophys Acta, 2006 Dec. PMID 16996694
    2. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular iron ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular iron ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal membrane ascorbate-dependent ferrireductase CYB561A3
    Names
    LCytb
    cytochrome b ascorbate-dependent protein 3
    cytochrome b, ascorbate dependent 3
    lysosomal cytochrome b
    NP_001014186.1
    XP_006231111.1
    XP_006231112.2
    XP_006231113.2
    XP_006231115.2
    XP_006231116.2
    XP_006231117.2
    XP_038940141.1
    XP_063124496.1
    XP_063124498.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014164.2 → NP_001014186.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

      See identical proteins and their annotated locations for NP_001014186.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5U2W7
      UniProtKB/TrEMBL
      A6I044
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216641108..216662495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231049.5 → XP_006231111.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X2

      UniProtKB/TrEMBL
      A6I044
      Conserved Domains (1) summary
      cl23723
      Location:39 → 217
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    2. XM_039084213.2 → XP_038940141.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X1

      UniProtKB/TrEMBL
      A6I044
      Conserved Domains (1) summary
      cl23723
      Location:39 → 217
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    3. XM_006231050.5 → XP_006231112.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    4. XM_006231051.5 → XP_006231113.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    5. XM_006231053.5 → XP_006231115.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    6. XM_006231054.5 → XP_006231116.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    7. XM_063268426.1 → XP_063124496.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044

    8. XM_006231055.5 → XP_006231117.2  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZL22, A6I044
      Related
      ENSRNOP00000078502.1, ENSRNOT00000113027.2
      Conserved Domains (1) summary
      cl23723
      Location:10 → 188
      Cytochrome_b_N; Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, ...

    9. XM_063268428.1 → XP_063124498.1  lysosomal membrane ascorbate-dependent ferrireductase CYB561A3 isoform X4

      UniProtKB/TrEMBL
      A0A8L2QF34, A6I044
      Related
      ENSRNOP00000028094.6, ENSRNOT00000028094.8
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U2W7.1 GenPept UniProtKB/Swiss-Prot:Q5U2W7

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