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    Spaca6 sperm acrosome associated 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688452, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spaca6provided by RGD
    Official Full Name
    sperm acrosome associated 6provided by RGD
    Primary source
    RGD:1588836
    See related
    EnsemblRapid:ENSRNOG00000039076 AllianceGenome:RGD:1588836
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in acrosomal vesicle. Orthologous to human SPACA6 (sperm acrosome associated 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 94.2), Kidney (RPKM 84.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spaca6 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (67345996..67365210)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (58672128..58689309)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (59700578..59719359)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor, pseudogene 20 Neighboring gene uncharacterized LOC102553133 Neighboring gene microRNA 3596c Neighboring gene microRNA let-7e Neighboring gene microRNA 125a Neighboring gene microRNA 99b Neighboring gene hyaluronan synthase 1 Neighboring gene U6 spliceosomal RNA Neighboring gene formyl peptide receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion. Lorenzetti D, et al. Mamm Genome, 2014 Apr. PMID 24275887
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm acrosome membrane-associated protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135720.1 → NP_001129192.1  sperm acrosome membrane-associated protein 6

      See identical proteins and their annotated locations for NP_001129192.1

      Status: PROVISIONAL

      Source sequence(s)
      FM212919
      UniProtKB/TrEMBL
      A6KB70, B6ETS2
      Related
      ENSRNOP00000014598.3, ENSRNOT00000014598.5
      Conserved Domains (2) summary
      smart00410
      Location:156 → 227
      IG_like; Immunoglobulin like
      cl11960
      Location:159 → 230
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      67345996..67365210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091151.2 → XP_038947079.1  sperm acrosome membrane-associated protein 6 isoform X11

      Conserved Domains (1) summary
      pfam13927
      Location:74 → 145
      Ig_3; Immunoglobulin domain

    2. XM_063274344.1 → XP_063130414.1  sperm acrosome membrane-associated protein 6 isoform X16

    3. XM_039091161.2 → XP_038947089.1  sperm acrosome membrane-associated protein 6 isoform X16

      Conserved Domains (2) summary
      pfam13927
      Location:20 → 91
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 34
      Ig; Ig strand B [structural motif]

    4. XM_039091180.2 → XP_038947108.1  sperm acrosome membrane-associated protein 6 isoform X18

      Conserved Domains (2) summary
      pfam13927
      Location:1 → 70
      Ig_3; Immunoglobulin domain
      cd00096
      Location:9 → 13
      Ig; Ig strand B [structural motif]

    5. XM_039091153.2 → XP_038947081.1  sperm acrosome membrane-associated protein 6 isoform X13

    6. XM_063274322.1 → XP_063130392.1  sperm acrosome membrane-associated protein 6 isoform X14

    7. XM_063274296.1 → XP_063130366.1  sperm acrosome membrane-associated protein 6 isoform X8

    8. XM_063274317.1 → XP_063130387.1  sperm acrosome membrane-associated protein 6 isoform X12

    9. XM_063274300.1 → XP_063130370.1  sperm acrosome membrane-associated protein 6 isoform X9

    10. XM_039091121.2 → XP_038947049.1  sperm acrosome membrane-associated protein 6 isoform X6

    11. XM_063274285.1 → XP_063130355.1  sperm acrosome membrane-associated protein 6 isoform X2

    12. XM_017589727.3 → XP_017445216.1  sperm acrosome membrane-associated protein 6 isoform X1

      Related
      ENSRNOP00000111659.1, ENSRNOT00000137994.1

    13. XM_017589729.3 → XP_017445218.1  sperm acrosome membrane-associated protein 6 isoform X3

    14. XM_039091149.2 → XP_038947077.1  sperm acrosome membrane-associated protein 6 isoform X11

      Conserved Domains (1) summary
      pfam13927
      Location:74 → 145
      Ig_3; Immunoglobulin domain

    15. XM_063274324.1 → XP_063130394.1  sperm acrosome membrane-associated protein 6 isoform X15

      UniProtKB/TrEMBL
      B8ZXH4

    16. XM_063274356.1 → XP_063130426.1  sperm acrosome membrane-associated protein 6 isoform X17

    17. XM_017589730.3 → XP_017445219.1  sperm acrosome membrane-associated protein 6 isoform X4

      UniProtKB/TrEMBL
      A6KB70

    18. XM_063274303.1 → XP_063130373.1  sperm acrosome membrane-associated protein 6 isoform X10

      UniProtKB/TrEMBL
      A6KB70

    19. XM_039091129.2 → XP_038947057.1  sperm acrosome membrane-associated protein 6 isoform X11

      Conserved Domains (1) summary
      pfam13927
      Location:74 → 145
      Ig_3; Immunoglobulin domain

    20. XM_039091134.2 → XP_038947062.1  sperm acrosome membrane-associated protein 6 isoform X11

      Conserved Domains (1) summary
      pfam13927
      Location:74 → 145
      Ig_3; Immunoglobulin domain

    21. XM_063274294.1 → XP_063130364.1  sperm acrosome membrane-associated protein 6 isoform X7

      UniProtKB/TrEMBL
      A6KB69

    22. XM_039091114.2 → XP_038947042.1  sperm acrosome membrane-associated protein 6 isoform X5

      UniProtKB/TrEMBL
      A6KB70
      Related
      ENSRNOP00000112053.1, ENSRNOT00000124112.1
      Conserved Domains (2) summary
      pfam13927
      Location:128 → 199
      Ig_3; Immunoglobulin domain
      cd00096
      Location:138 → 142
      Ig; Ig strand B [structural motif]

    23. XM_039091155.2 → XP_038947083.1  sperm acrosome membrane-associated protein 6 isoform X16

      Conserved Domains (2) summary
      pfam13927
      Location:20 → 91
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 34
      Ig; Ig strand B [structural motif]

    24. XM_039091158.2 → XP_038947086.1  sperm acrosome membrane-associated protein 6 isoform X16

      Conserved Domains (2) summary
      pfam13927
      Location:20 → 91
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 34
      Ig; Ig strand B [structural motif]

    25. XM_039091160.2 → XP_038947088.1  sperm acrosome membrane-associated protein 6 isoform X16

      Conserved Domains (2) summary
      pfam13927
      Location:20 → 91
      Ig_3; Immunoglobulin domain
      cd00096
      Location:30 → 34
      Ig; Ig strand B [structural motif]

    26. XM_063274332.1 → XP_063130402.1  sperm acrosome membrane-associated protein 6 isoform X16

    27. XM_063274335.1 → XP_063130405.1  sperm acrosome membrane-associated protein 6 isoform X16

    28. XM_039091142.2 → XP_038947070.1  sperm acrosome membrane-associated protein 6 isoform X11

      Conserved Domains (1) summary
      pfam13927
      Location:74 → 145
      Ig_3; Immunoglobulin domain

    29. XM_063274346.1 → XP_063130416.1  sperm acrosome membrane-associated protein 6 isoform X16

    30. XM_039091177.2 → XP_038947105.1  sperm acrosome membrane-associated protein 6 isoform X18

      Conserved Domains (2) summary
      pfam13927
      Location:1 → 70
      Ig_3; Immunoglobulin domain
      cd00096
      Location:9 → 13
      Ig; Ig strand B [structural motif]

    RNA

    1. XR_005492294.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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