Rhbdf1 rhomboid 5 homolog 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rhbdf1provided by RGD
Official Full Name: rhomboid 5 homolog 1provided by RGD
Primary source: RGD:1305075
See related: EnsemblRapid:ENSRNOG00000020594 AllianceGenome:RGD:1305075
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable growth factor binding activity. Predicted to be involved in several processes, including negative regulation of protein secretion; regulation of epidermal growth factor receptor signaling pathway; and regulation of proteasomal protein catabolic process. Predicted to be located in Golgi membrane. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human RHBDF1 (rhomboid 5 homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 43.2), Kidney (RPKM 38.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (15911282..15924214)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (15406832..15419765)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (15672370..15685285)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables growth factor binding	IEA Inferred from Electronic Annotation more info
NOT enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
NOT enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of protein secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: inactive rhomboid protein 1

Names: iRhom1; rhomboid family 1; rhomboid family member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030034.2 → NP_001025205.1 inactive rhomboid protein 1

See identical proteins and their annotated locations for NP_001025205.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q499S9

UniProtKB/TrEMBL

A6HDB3

Related

ENSRNOP00000027965.3, ENSRNOT00000027965.6

Conserved Domains (2) summary

pfam01694
Location:648 → 789

Rhomboid; Rhomboid family

pfam12595
Location:91 → 308

Rhomboid_SP; Rhomboid serine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

15911282..15924214

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085877.2 → XP_038941805.1 inactive rhomboid protein 1 isoform X1

Conserved Domains (2) summary

pfam01694
Location:699 → 840

Rhomboid; Rhomboid family

pfam12595
Location:142 → 359

Rhomboid_SP; Rhomboid serine protease
XM_039085881.2 → XP_038941809.1 inactive rhomboid protein 1 isoform X2

Related

ENSRNOP00000112746.1, ENSRNOT00000145512.1

Conserved Domains (2) summary

pfam01694
Location:683 → 824

Rhomboid; Rhomboid family

pfam12595
Location:126 → 343

Rhomboid_SP; Rhomboid serine protease
XM_039085878.2 → XP_038941806.1 inactive rhomboid protein 1 isoform X1

Conserved Domains (2) summary

pfam01694
Location:699 → 840

Rhomboid; Rhomboid family

pfam12595
Location:142 → 359

Rhomboid_SP; Rhomboid serine protease
XM_063268948.1 → XP_063125018.1 inactive rhomboid protein 1 isoform X3

UniProtKB/Swiss-Prot

Q499S9

UniProtKB/TrEMBL

A6HDB3
XM_039085879.2 → XP_038941807.1 inactive rhomboid protein 1 isoform X1

Conserved Domains (2) summary

pfam01694
Location:699 → 840

Rhomboid; Rhomboid family

pfam12595
Location:142 → 359

Rhomboid_SP; Rhomboid serine protease
XM_063268949.1 → XP_063125019.1 inactive rhomboid protein 1 isoform X3

UniProtKB/Swiss-Prot

Q499S9

UniProtKB/TrEMBL

A6HDB3
XM_039085880.2 → XP_038941808.1 inactive rhomboid protein 1 isoform X1

Conserved Domains (2) summary

pfam01694
Location:699 → 840

Rhomboid; Rhomboid family

pfam12595
Location:142 → 359

Rhomboid_SP; Rhomboid serine protease
XM_063268951.1 → XP_063125021.1 inactive rhomboid protein 1 isoform X3

UniProtKB/Swiss-Prot

Q499S9

UniProtKB/TrEMBL

A6HDB3
XM_063268950.1 → XP_063125020.1 inactive rhomboid protein 1 isoform X3

UniProtKB/Swiss-Prot

Q499S9

UniProtKB/TrEMBL

A6HDB3