Mknk1 MAPK interacting serine/threonine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mknk1provided by RGD
Official Full Name: MAPK interacting serine/threonine kinase 1provided by RGD
Primary source: RGD:1559603
See related: EnsemblRapid:ENSRNOG00000010381 AllianceGenome:RGD:1559603
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation and regulation of translational initiation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK1 (MAPK interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 76.3), Adrenal (RPKM 75.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5q35

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (134554881..134594392)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (129318128..129357641)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (134691852..134730887)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Long-term potentiation (LTP) consolidation in the dentate gyrus of live rodents requires sustained (hours) BDNF-TrkB signaling and from TrkB to MAP-kinase-interacting kinase.
Title: Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

BI301014 (e-PCR)
- UniSTS:246683

D5Mco7 (e-PCR)
- UniSTS:240066

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium/calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to salt stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: MAP kinase-interacting serine/threonine-protein kinase 1

Names: MAP kinase signal-integrating kinase 1; MAP kinase-interacting serine/threonine kinase 1; MAPK signal-integrating kinase 1; mnk1

NP_001037732.1

EC 2.7.11.1

XP_006238756.1

EC 2.7.11.1

XP_006238758.1

EC 2.7.11.1

XP_006238759.1

EC 2.7.11.1

XP_006238760.1

EC 2.7.11.1

XP_038966512.1

EC 2.7.11.1

XP_038966513.1

EC 2.7.11.1

XP_038966514.1

EC 2.7.11.1

XP_038966515.1

EC 2.7.11.1

XP_063144306.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044267.1 → NP_001037732.1 MAP kinase-interacting serine/threonine-protein kinase 1

See identical proteins and their annotated locations for NP_001037732.1

Status: PROVISIONAL

Source sequence(s)

BC098754

UniProtKB/Swiss-Prot

Q4G050

UniProtKB/TrEMBL

A0A8L2QVH8, A6JZ51

Conserved Domains (1) summary

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

134554881..134594392

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006238697.4 → XP_006238759.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

See identical proteins and their annotated locations for XP_006238759.1

UniProtKB/TrEMBL

A0A0G2K3K7, A0A8L2QVH8

Related

ENSRNOP00000072679.2, ENSRNOT00000091543.3

Conserved Domains (2) summary

smart00220
Location:47 → 327

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_063288236.1 → XP_063144306.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X8
XM_006238696.5 → XP_006238758.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2

See identical proteins and their annotated locations for XP_006238758.1

UniProtKB/TrEMBL

A0A0G2K3K7, A0A8L2QVH8

Related

ENSRNOP00000061535.4, ENSRNOT00000067655.4

Conserved Domains (2) summary

smart00220
Location:47 → 327

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_006238698.5 → XP_006238760.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X3

See identical proteins and their annotated locations for XP_006238760.1

UniProtKB/Swiss-Prot

Q4G050

UniProtKB/TrEMBL

A0A8L2QVH8, A6JZ51

Conserved Domains (1) summary

cd14174
Location:34 → 322

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_039110587.2 → XP_038966515.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X7

Conserved Domains (1) summary

cl21453
Location:31 → 200

PKc_like; Protein Kinases, catalytic domain
XM_039110585.2 → XP_038966513.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X5

UniProtKB/TrEMBL

A0A8L2QVH8

Conserved Domains (1) summary

cd14174
Location:40 → 328

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1
XM_039110586.1 → XP_038966514.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X6

Related

ENSRNOP00000102287.1, ENSRNOT00000138277.1

Conserved Domains (1) summary

cl21453
Location:40 → 209

PKc_like; Protein Kinases, catalytic domain
XM_039110584.1 → XP_038966512.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X4

Conserved Domains (1) summary

cl21453
Location:40 → 209

PKc_like; Protein Kinases, catalytic domain
XM_006238694.5 → XP_006238756.1 MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1

UniProtKB/TrEMBL

A0A8L2QVH8

Related

ENSRNOP00000112550.1, ENSRNOT00000121912.1

Conserved Domains (2) summary

smart00220
Location:74 → 354

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14174
Location:67 → 355

STKc_Mnk1; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1