Gemin4 gem (nuclear organelle) associated protein 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gemin4provided by RGD
Official Full Name: gem (nuclear organelle) associated protein 4provided by RGD
Primary source: RGD:1563715
See related: EnsemblRapid:ENSRNOG00000055236 AllianceGenome:RGD:1563715
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1563715
Summary: Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in spliceosomal snRNP assembly. Predicted to be located in Cajal body; cytosol; and nucleolus. Predicted to be part of SMN complex. Human ortholog(s) of this gene implicated in alcohol dependence and neurodevelopmental disorder with microcephaly, cataracts, and renal abnormalities. Orthologous to human GEMIN4 (gem nuclear organelle associated protein 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 88.7), Adrenal (RPKM 78.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (61560172..61571765, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (61062420..61073529, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (64364808..64375885, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that GEMIN4 functions as a novel coregulator of the MR.
Title: GEMIN4 functions as a coregulator of the mineralocorticoid receptor.

Submit: New GeneRIF Correction

General gene information

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Markers

RH134905 (e-PCR)
- UniSTS:218183

D11S3159 (e-PCR)
- UniSTS:152247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribonucleoprotein complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
part_of SMN complex	ISO Inferred from Sequence Orthology more info
part_of SMN-Sm protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gem-associated protein 4

Names: component of gems 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.