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    Plekhg5 pleckstrin homology and RhoGEF domain containing G5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekhg5provided by RGD
    Official Full Name
    pleckstrin homology and RhoGEF domain containing G5provided by RGD
    Primary source
    RGD:1303132
    See related
    EnsemblRapid:ENSRNOG00000022694 AllianceGenome:RGD:1303132
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tech
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including endothelial cell chemotaxis; positive regulation of canonical NF-kappaB signal transduction; and regulation protein catabolic process at presynapse. Predicted to be located in several cellular components, including cell-cell junction; lamellipodium; and presynapse. Predicted to be active in axon; endocytic vesicle; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and autosomal recessive distal hereditary motor neuronopathy 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 54.7), Adrenal (RPKM 47.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekhg5 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167860730..167904229)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162577999..162621518)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169244778..169288310)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene taste 1 receptor member 1 Neighboring gene nucleolar protein 9 Neighboring gene TNF receptor superfamily member 25 Neighboring gene espin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension. Cario-Toumaniantz C, et al. Am J Physiol Cell Physiol, 2012 May 1. PMID 22322975
    2. Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons. Marx R, et al. J Neurochem, 2005 Feb. PMID 15686487
    3. The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1. Estévez MA, et al. J Neurochem, 2008 Aug. PMID 18537874, Free PMC Article
    4. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Lüningschrör P, et al. Nat Commun, 2017 Oct 30. PMID 29084947, Free PMC Article
    5. A PDZ-binding motif as a critical determinant of Rho guanine exchange factor function and cell phenotype. Liu M, et al. Mol Biol Cell, 2006 Apr. PMID 16467373, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work thus identifies a group of RhoA-GEFs that controls RhoA and RhoA-dependent functions in vascular smooth muscle cells
      Title: RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension.
    2. Tech regulates RhoA signaling pathways in developing and mature forebrain neurons.
      Title: Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endothelial cell chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation protein catabolic process at presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family G member 5
    Names
    PH domain-containing family G member 5
    neuronal RhoA GEF protein
    pleckstrin homology domain containing, family G (with RhoGef domain) member 5
    transcript highly enriched in cortex and hippocampus

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415855.1 → NP_001402784.1  pleckstrin homology domain-containing family G member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K8X8, A0A8I6AJ37
      Related
      ENSRNOP00000093604.2, ENSRNOT00000107438.2

    2. NM_001415856.1 → NP_001402785.1  pleckstrin homology domain-containing family G member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0G2K1M4, A0A0G2K8X8
      Related
      ENSRNOP00000104105.1, ENSRNOT00000139516.1

    3. NM_201272.2 → NP_958429.1  pleckstrin homology domain-containing family G member 5 isoform 3

      See identical proteins and their annotated locations for NP_958429.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q6RFZ7
      UniProtKB/TrEMBL
      A0A0G2K8X8
      Related
      ENSRNOP00000059729.1, ENSRNOT00000064841.4
      Conserved Domains (4) summary
      smart00325
      Location:376 → 562
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:619 → 717
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      cd17068
      Location:110 → 184
      RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
      pfam03154
      Location:851 → 1015
      Atrophin-1; Atrophin-1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      167860730..167904229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109738.2 → XP_038965666.1  pleckstrin homology domain-containing family G member 5 isoform X3

      UniProtKB/Swiss-Prot
      Q6RFZ7
      UniProtKB/TrEMBL
      A0A0G2K8X8
      Conserved Domains (4) summary
      smart00325
      Location:376 → 562
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:619 → 717
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      cd17068
      Location:110 → 184
      RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
      pfam03154
      Location:851 → 1015
      Atrophin-1; Atrophin-1 family

    2. XM_039109735.2 → XP_038965663.1  pleckstrin homology domain-containing family G member 5 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K8X8, A0A8I6A5Z3
      Related
      ENSRNOP00000088309.1, ENSRNOT00000118143.2
      Conserved Domains (4) summary
      smart00325
      Location:438 → 624
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:681 → 779
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      cd17068
      Location:172 → 246
      RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
      pfam03154
      Location:913 → 1077
      Atrophin-1; Atrophin-1 family

    3. XM_039109734.2 → XP_038965662.1  pleckstrin homology domain-containing family G member 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K8X8
      Conserved Domains (4) summary
      smart00325
      Location:394 → 580
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:637 → 735
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      cd17068
      Location:128 → 202
      RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
      pfam03154
      Location:869 → 1033
      Atrophin-1; Atrophin-1 family

    4. XM_039109739.2 → XP_038965667.1  pleckstrin homology domain-containing family G member 5 isoform X3

      UniProtKB/Swiss-Prot
      Q6RFZ7
      UniProtKB/TrEMBL
      A0A0G2K8X8
      Conserved Domains (4) summary
      smart00325
      Location:376 → 562
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd13244
      Location:619 → 717
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      cd17068
      Location:110 → 184
      RBD_PLEKHG5; Ras-binding domain (RBD) found in pleckstrin homology (PH) and RhoGEF domain containing G5 (PLEKHG5) and similar proteins
      pfam03154
      Location:851 → 1015
      Atrophin-1; Atrophin-1 family

    5. XM_039109740.2 → XP_038965668.1  pleckstrin homology domain-containing family G member 5 isoform X4

      Conserved Domains (3) summary
      cd13244
      Location:182 → 280
      PH_PLEKHG5_G6; Pleckstrin homology domain-containing family G member 5 and 6 pleckstrin homology (PH) domain
      pfam00621
      Location:20 → 125
      RhoGEF; RhoGEF domain
      pfam03154
      Location:414 → 578
      Atrophin-1; Atrophin-1 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RFZ7.1 GenPept UniProtKB/Swiss-Prot:Q6RFZ7

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