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    Snx21 sorting nexin family member 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362940, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx21provided by RGD
    Official Full Name
    sorting nexin family member 21provided by RGD
    Primary source
    RGD:2323753
    See related
    AllianceGenome:RGD:2323753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3-phosphate binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in protein transport. Predicted to be located in early endosome membrane. Orthologous to human SNX21 (sorting nexin family member 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 83.1), Brain (RPKM 68.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx21 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173941634..173951571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153522474..153532235)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161252634..161261880)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2C Neighboring gene troponin C2, fast skeletal type Neighboring gene acyl-CoA thioesterase 8 Neighboring gene zinc finger, SWIM-type containing 3 Neighboring gene zinc finger, SWIM-type containing 1 Neighboring gene spermatogenesis associated 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and Membrane Binding Properties of the Endosomal Tetratricopeptide Repeat (TPR) Domain-containing Sorting Nexins SNX20 and SNX21. Clairfeuille T, et al. J Biol Chem, 2015 Jun 5. PMID 25882846, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-21
    Names
    sorting nexin 21
    sorting nexin 21-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399714.1 → NP_001386643.1  sorting nexin-21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZZC7
      Conserved Domains (3) summary
      sd00006
      Location:234 → 258
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:234 → 303
      TPR_12; Tetratricopeptide repeat
      cl02563
      Location:121 → 232
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001399715.1 → NP_001386644.1  sorting nexin-21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173941634..173951571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282970.1 → XP_063139040.1  sorting nexin-21 isoform X3

      UniProtKB/TrEMBL
      A0A8I6G3Q7

    2. XM_063282969.1 → XP_063139039.1  sorting nexin-21 isoform X1

    3. XM_039106723.2 → XP_038962651.2  sorting nexin-21 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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