Asxl2 ASXL transcriptional regulator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asxl2provided by RGD
Official Full Name: ASXL transcriptional regulator 2provided by RGD
Primary source: RGD:1304710
See related: EnsemblRapid:ENSRNOG00000011908 AllianceGenome:RGD:1304710
Gene type: protein coding
RefSeq status: MODEL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity and peroxisome proliferator activated receptor binding activity. Involved in positive regulation of lipid storage. Predicted to be located in nucleoplasm. Predicted to be part of PR-DUB complex. Orthologous to human ASXL2 (ASXL transcriptional regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 128.0), Kidney (RPKM 116.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (32090497..32234487)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (26425017..26514899)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (27835346..27919285)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overall, these results support the reciprocal role of the ASXL family in lipid homeostasis through the opposite regulation of LXRalpha.
Title: Reciprocal regulation of LXRα activity by ASXL1 and ASXL2 in lipogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

BF404323 (e-PCR)
- UniSTS:247043

AU048346 (e-PCR)
- UniSTS:109626

RH140747 (e-PCR)
- UniSTS:222813

BF399538 (e-PCR)
- UniSTS:247714

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxisome proliferator activated receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables peroxisome proliferator activated receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult heart development	ISO Inferred from Sequence Orthology more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transferase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PR-DUB complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ASXL transcriptional regulator 2; putative Polycomb group protein ASXL2

Names: additional sex combs like 2, transcriptional regulator; additional sex combs like transcriptional regulator 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

32090497..32234487

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063262612.1 → XP_063118682.1 putative Polycomb group protein ASXL2 isoform X3

UniProtKB/TrEMBL

D3Z8N9
XM_063262610.1 → XP_063118680.1 putative Polycomb group protein ASXL2 isoform X1

UniProtKB/TrEMBL

D3Z8N9

Related

ENSRNOP00000081020.2, ENSRNOT00000105980.2
XM_063262611.1 → XP_063118681.1 putative Polycomb group protein ASXL2 isoform X2

UniProtKB/TrEMBL

D3Z8N9

Related

ENSRNOP00000015827.9, ENSRNOT00000015827.10
XM_063262613.1 → XP_063118683.1 putative Polycomb group protein ASXL2 isoform X3

UniProtKB/TrEMBL

D3Z8N9
XM_063262617.1 → XP_063118687.1 putative Polycomb group protein ASXL2 isoform X4

UniProtKB/TrEMBL

D3Z8N9
XM_063262616.1 → XP_063118686.1 putative Polycomb group protein ASXL2 isoform X4

UniProtKB/TrEMBL

D3Z8N9
XM_063262615.1 → XP_063118685.1 putative Polycomb group protein ASXL2 isoform X4

UniProtKB/TrEMBL

D3Z8N9
XM_063262614.1 → XP_063118684.1 putative Polycomb group protein ASXL2 isoform X4

UniProtKB/TrEMBL

D3Z8N9
XM_063262618.1 → XP_063118688.1 putative Polycomb group protein ASXL2 isoform X4

UniProtKB/TrEMBL

D3Z8N9
XM_063262619.1 → XP_063118689.1 putative Polycomb group protein ASXL2 isoform X5

UniProtKB/TrEMBL

D3Z8N9
XM_063262620.1 → XP_063118690.1 putative Polycomb group protein ASXL2 isoform X6

UniProtKB/TrEMBL

D3Z8N9

RNA

XR_010052213.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001108011.1: Suppressed sequence

Description

NM_001108011.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: ASXL2 (GeneID:421993).