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    Efcab14 EF-hand calcium binding domain 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298425, updated on 9-Dec-2024

    Summary

    Official Symbol
    Efcab14provided by RGD
    Official Full Name
    EF-hand calcium binding domain 14provided by RGD
    Primary source
    RGD:1310351
    See related
    EnsemblRapid:ENSRNOG00000010091 AllianceGenome:RGD:1310351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310351
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be located in membrane. Orthologous to human EFCAB14 (EF-hand calcium binding domain 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 180.9), Kidney (RPKM 174.1) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Efcab14 in Genome Data Viewer
    Location:
    5q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134454908..134493714)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129218139..129258628)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (134594012..134632168)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily b, polypeptide 1 Neighboring gene farnesyl diphosphate synthase, pseudogene 2 Neighboring gene uncharacterized LOC134487082 Neighboring gene testis expressed 38 Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    EF-hand calcium-binding domain-containing protein 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106677.2NP_001100147.1  EF-hand calcium-binding domain-containing protein 14

      See identical proteins and their annotated locations for NP_001100147.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AQN0, A6JZ45, D3ZTM7
      Related
      ENSRNOP00000013471.5, ENSRNOT00000013471.9
      Conserved Domains (2) summary
      COG1196
      Location:97344
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl08302
      Location:427478
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134454908..134493714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287401.1XP_063143471.1  EF-hand calcium-binding domain-containing protein 14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUW4
    2. XM_039109592.2XP_038965520.1  EF-hand calcium-binding domain-containing protein 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLM3, A0A8I6AQN0
      Related
      ENSRNOP00000078819.1, ENSRNOT00000100267.2
      Conserved Domains (2) summary
      COG1196
      Location:97344
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl08302
      Location:427478
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...