Mmrn2 multimerin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mmrn2provided by RGD
Official Full Name: multimerin 2provided by RGD
Primary source: RGD:1311461
See related: EnsemblRapid:ENSRNOG00000051977 AllianceGenome:RGD:1311461
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable receptor ligand activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and negative regulation of cell migration involved in sprouting angiogenesis. Predicted to be located in basement membrane and extracellular space. Orthologous to human MMRN2 (multimerin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 159.0), Lung (RPKM 138.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (9712181..9733653)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (9705925..9727405)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (10727552..10749303)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128709 (e-PCR)
- UniSTS:212017

RH137519 (e-PCR)
- UniSTS:219607

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial tube formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multimerin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001372014.1 → NP_001358943.1 multimerin-2 precursor

Status: VALIDATED

Source sequence(s)

FQ218167, JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6GHU7

Related

ENSRNOP00000074627.2, ENSRNOT00000084422.3

Conserved Domains (4) summary

TIGR02168
Location:518 → 777

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam15921
Location:249 → 585

CCDC158; Coiled-coil domain-containing protein 158

pfam00386
Location:811 → 930

C1q; C1q domain

pfam07546
Location:57 → 127

EMI; EMI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

9712181..9733653

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094475.2 → XP_038950403.1 multimerin-2 isoform X1

UniProtKB/TrEMBL

A0A8I6GHU7

Related

ENSRNOP00000089998.2, ENSRNOT00000110870.2

Conserved Domains (3) summary

pfam15921
Location:292 → 650

CCDC158; Coiled-coil domain-containing protein 158

pfam00386
Location:854 → 973

C1q; C1q domain

pfam07546
Location:100 → 170

EMI; EMI domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001107298.1: Suppressed sequence

Description

NM_001107298.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MMRN2 (GeneID:79812).