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    Amn1 antagonist of mitotic exit network 1 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Amn1provided by RGD
    Official Full Name
    antagonist of mitotic exit network 1 homologprovided by RGD
    Primary source
    RGD:1308119
    See related
    EnsemblRapid:ENSRNOG00000036917 AllianceGenome:RGD:1308119
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308119
    Summary
    Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in microvillus membrane. Orthologous to human AMN1 (antagonist of mitotic exit network 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 100.6), Spleen (RPKM 70.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Amn1 in Genome Data Viewer
    Location:
    4q44
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (183886469..183913411, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (182155140..182182085, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183670589..183697531, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene DENN domain containing 5B Neighboring gene U6 spliceosomal RNA Neighboring gene mesoderm specific transcript, pseudogene 1 Neighboring gene electron transfer flavoprotein subunit beta lysine methyltransferase Neighboring gene adenosylhomocysteinase-like Neighboring gene basic transcription factor 3, pseudogene 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060780, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105998

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein AMN1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008333.2 → NP_001008334.2  protein AMN1 homolog

      See identical proteins and their annotated locations for NP_001008334.2

      Status: VALIDATED

      Source sequence(s)
      BC086357, BG672304
      UniProtKB/Swiss-Prot
      Q5U201
      UniProtKB/TrEMBL
      A0A8L2QRD5, A6IN73
      Related
      ENSRNOP00000089244.2, ENSRNOT00000117439.2
      Conserved Domains (2) summary
      cd09293
      Location:37 → 257
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:63 → 86
      LRR_AMN1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      183886469..183913411 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237700.3 → XP_006237762.1  protein AMN1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABJ0, A0A8L2QRD5
      Conserved Domains (2) summary
      cd09293
      Location:1 → 214
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:20 → 43
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5U201.2 GenPept UniProtKB/Swiss-Prot:Q5U201

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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