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    Fndc3a fibronectin type III domain containing 3a [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306022, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fndc3aprovided by RGD
    Official Full Name
    fibronectin type III domain containing 3aprovided by RGD
    Primary source
    RGD:1304736
    See related
    EnsemblRapid:ENSRNOG00000014478 AllianceGenome:RGD:1304736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fndc3
    Summary
    Predicted to be involved in spermatid development. Predicted to act upstream of or within Sertoli cell development; cell-cell adhesion; and fertilization. Predicted to be located in several cellular components, including Golgi apparatus; acrosomal vesicle; and vesicle membrane. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Orthologous to human FNDC3A (fibronectin type III domain containing 3A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 103.1), Kidney (RPKM 100.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fndc3a in Genome Data Viewer
    Location:
    15p11
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (54099510..54276963, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (47689909..47867354, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (54378865..54582954, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554611 Neighboring gene uncharacterized LOC134481987 Neighboring gene uncharacterized LOC134482148 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing protein 2-like 2, pseudogene 5 Neighboring gene uncharacterized LOC120097033

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HUGO (FNDC3A): a new gene overexpressed in human odontoblasts. Carrouel F, et al. J Dent Res, 2008 Feb. PMID 18218838
    2. Testis structure in the sys (symplastic spermatids) mouse. Russell LD, et al. Am J Anat, 1991 Oct. PMID 1759682
    3. FNDC3A is required for adhesion between spermatids and Sertoli cells. Obholz KL, et al. Dev Biol, 2006 Oct 15. PMID 16904100, Free PMC Article
    4. Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. MacGregor GR, et al. Proc Natl Acad Sci U S A, 1990 Jul. PMID 2164218, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Sertoli cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fibronectin type-III domain-containing protein 3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412039.1 → NP_001398968.1  fibronectin type-III domain-containing protein 3A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZVT2, A6HTP1, D3ZEA0, D3ZUE6
      Related
      ENSRNOP00000082902.1, ENSRNOT00000111875.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      54099510..54276963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252298.5 → XP_006252360.1  fibronectin type-III domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006252360.1

      UniProtKB/TrEMBL
      A0A8I5ZVT2, A6HTP1, D3ZEA0, D3ZUE6
      Related
      ENSRNOP00000093978.2, ENSRNOT00000100330.2
      Conserved Domains (1) summary
      cd00063
      Location:372 → 463
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    2. XM_006252297.4 → XP_006252359.1  fibronectin type-III domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006252359.1

      UniProtKB/TrEMBL
      A0A8I5ZVT2, A6HTP1, D3ZEA0, D3ZUE6
      Conserved Domains (1) summary
      cd00063
      Location:372 → 463
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    3. XM_006252296.5 → XP_006252358.1  fibronectin type-III domain-containing protein 3A isoform X1

      See identical proteins and their annotated locations for XP_006252358.1

      UniProtKB/TrEMBL
      A0A8I5ZVT2, A6HTP1, D3ZEA0, D3ZUE6
      Conserved Domains (1) summary
      cd00063
      Location:372 → 463
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    4. XM_039093358.1 → XP_038949286.1  fibronectin type-III domain-containing protein 3A isoform X4

      UniProtKB/TrEMBL
      A0A8I6AXU9
      Conserved Domains (1) summary
      cd00063
      Location:346 → 437
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    5. XM_006252299.5 → XP_006252361.1  fibronectin type-III domain-containing protein 3A isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5F5, A0A8I6AXU9
      Related
      ENSRNOP00000062773.3, ENSRNOT00000066888.5
      Conserved Domains (1) summary
      cd00063
      Location:360 → 451
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    6. XM_006252300.5 → XP_006252362.3  fibronectin type-III domain-containing protein 3A isoform X3

      UniProtKB/TrEMBL
      A0A8I6AXU9

    7. XM_006252301.5 → XP_006252363.1  fibronectin type-III domain-containing protein 3A isoform X5

      UniProtKB/TrEMBL
      A0A8I6AMX6, A0A8I6AXU9
      Related
      ENSRNOP00000087923.2, ENSRNOT00000096165.2
      Conserved Domains (1) summary
      cd00063
      Location:315 → 406
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    Nucleotide Protein Strain
    Heading Accession and Version

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