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    Ccdc85c coiled-coil domain containing 85C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690965, updated on 9-Dec-2024

    Summary

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    Symbol
    Ccdc85cprovided by RGD
    Full Name
    coiled-coil domain containing 85Cprovided by RGD
    Primary source
    RGD:1589818
    See related
    EnsemblRapid:ENSRNOG00000065213 AllianceGenome:RGD:1589818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cerebral cortex development. Predicted to act upstream of or within several processes, including Notch signaling pathway; establishment of cell polarity; and radial glial cell differentiation. Predicted to be located in adherens junction and apical junction complex. Used to study hydrocephalus. Orthologous to human CCDC85C (coiled-coil domain containing 85C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 322.2), Heart (RPKM 94.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc85c in Genome Data Viewer
    Location:
    6q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (132877851..132948744, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127113440..127184328, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132113806..132183434, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene SET domain containing 3, actin N3(tau)-histidine methyltransferase Neighboring gene cyclin K Neighboring gene uncharacterized LOC120103617 Neighboring gene uncharacterized LOC120103618 Neighboring gene HHIP-like 1 Neighboring gene cytochrome P450, family 46, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats. Hasan MM, et al. Exp Anim, 2022 Feb 9. PMID 34657927, Free PMC Article
    2. Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus. Konishi S, et al. Exp Anim, 2020 Jan 29. PMID 31341137, Free PMC Article
    3. Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats. Tanaka N, et al. Histol Histopathol, 2015 Jul. PMID 25644709
    4. Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice. Mori N, et al. Am J Pathol, 2012 Jan. PMID 22056358

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats.
      Title: Expression of CCDC85C, a causative protein for hydrocephalus, and intermediate filament proteins during lateral ventricle development in rats.
    2. These results indicate that CCDC85C plays an important role in cerebral development in rats, and the function of CCDC85C in the cerebrum are similar in rats and mice.
      Title: Pathological characteristics of Ccdc85c knockout rats: a rat model of genetic hydrocephalus.
    3. Distribution of Ccdc85C coincides with that of proliferating epithelial cells. These results suggest that Ccdc85C plays an important role in the proliferative property of simple epithelia.
      Title: Ccdc85C, a causative protein for hydrocephalus and subcortical heterotopia, is expressed in the systemic epithelia with proliferative activity in rats.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of cell polarity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within radial glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical junction complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain containing 85C; coiled-coil domain-containing protein 85C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433239.1 → NP_001420168.1  coiled-coil domain containing 85C isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6GKA8

    2. NM_001433240.1 → NP_001420169.1  coiled-coil domain containing 85C isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001433241.1 → NP_001420170.1  coiled-coil domain containing 85C isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5YBH3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      132877851..132948744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039113371.2 → XP_038969299.1  coiled-coil domain-containing protein 85C isoform X2

      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    2. XM_006240553.3 → XP_006240615.2  coiled-coil domain-containing protein 85C isoform X1

      Related
      ENSRNOP00000076803.1, ENSRNOT00000095434.2
      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    3. XM_039113373.2 → XP_038969301.1  coiled-coil domain-containing protein 85C isoform X4

      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family

    4. XM_039113372.2 → XP_038969300.1  coiled-coil domain-containing protein 85C isoform X3

      Related
      ENSRNOP00000093459.1, ENSRNOT00000104756.2
      Conserved Domains (1) summary
      pfam10226
      Location:16 → 203
      CCDC85; CCDC85 family
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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