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    Acot3 acyl-CoA thioesterase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acot3provided by RGD
    Official Full Name
    acyl-CoA thioesterase 3provided by RGD
    Primary source
    RGD:1564089
    See related
    EnsemblRapid:ENSRNOG00000027960 AllianceGenome:RGD:1564089
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564089
    Summary
    Predicted to enable fatty acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process and carboxylic acid metabolic process. Predicted to be located in cytosol and peroxisome. Orthologous to human ACOT1 (acyl-CoA thioesterase 1) and ACOT2 (acyl-CoA thioesterase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 132.5), Heart (RPKM 73.7) and 9 other tissues See more
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    Genomic context

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    See Acot3 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109413617..109419840)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103682518..103688735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107531508..107537446)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L23A like 8 Neighboring gene acyl-CoA thioesterase 4 Neighboring gene acyl-CoA thioesterase 5 Neighboring gene uncharacterized LOC134479230

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. Westin MA, et al. J Biol Chem, 2004 May 21. PMID 15007068
    2. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. Hunt MC, et al. FASEB J, 2006 Sep. PMID 16940157
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acyl-CoA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in saturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in unsaturated monocarboxylic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in very long-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA thioesterase 3
    NP_001101511.1
    XP_038968231.1
    XP_038968233.1
    XP_038968234.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108041.1 → NP_001101511.1  acyl-CoA thioesterase 3

      See identical proteins and their annotated locations for NP_001101511.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A0A8I6A6H9, A6JDS8
      Conserved Domains (3) summary
      pfam04775
      Location:26 → 146
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:212 → 421
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
      cl21494
      Location:146 → 262
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      109413617..109419840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112306.2 → XP_038968234.1  acyl-CoA thioesterase 3 isoform X3

      Conserved Domains (2) summary
      pfam04775
      Location:25 → 146
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:203 → 221
      Abhydrolase; alpha/beta hydrolases

    2. XM_039112305.2 → XP_038968233.1  acyl-CoA thioesterase 3 isoform X2

      Conserved Domains (2) summary
      pfam04775
      Location:25 → 146
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      cl21494
      Location:212 → 230
      Abhydrolase; alpha/beta hydrolases

    3. XM_039112303.2 → XP_038968231.1  acyl-CoA thioesterase 3 isoform X1

      Related
      ENSRNOP00000086778.2, ENSRNOT00000039048.7
      Conserved Domains (2) summary
      pfam04775
      Location:25 → 146
      Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region
      pfam08840
      Location:203 → 412
      BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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