Slc26a6 solute carrier family 26 member 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a6provided by RGD
Official Full Name: solute carrier family 26 member 6provided by RGD
Primary source: RGD:1310197
See related: EnsemblRapid:ENSRNOG00000020450 AllianceGenome:RGD:1310197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including PDZ domain binding activity; identical protein binding activity; and organic anion transmembrane transporter activity. Involved in estrous cycle. Located in apical plasma membrane. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 54.7), Muscle (RPKM 38.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (118438110..118448271)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (109558968..109569778)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (117648792..117659376)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

reducing the expression of Slc26a6 in the kidney may be a potential strategy for preventing stone formation.
Title: Downregulated Expression of Solute Carrier Family 26 Member 6 in NRK-52E Cells Attenuates Oxalate-Induced Intracellular Oxidative Stress.
Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats.
Title: Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.
Progestore inhibits CFTR and SLC26A6 proteins and mRNA expression while oestrogen (E) causes vice versa.
Title: Progesterone downregulates oestrogen-induced expression of CFTR and SLC26A6 proteins and mRNA in rats' uteri.
SLC26A6 is at least one of the anion exchanger's family members responsible for Cl-/HCO3- exchange in IEC-6 cells.
Title: Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).

Submit: New GeneRIF Correction

General gene information

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Markers

AI111610 (e-PCR)
- UniSTS:245049

RH131067 (e-PCR)
- UniSTS:214350

ksks342 (e-PCR)
- UniSTS:514389

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables formate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables solute:inorganic anion antiporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiotensin-activated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to fructose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in epithelial fluid transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in estrous cycle	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within formate transport	ISO Inferred from Sequence Orthology more info
involved_in formate transport	ISO Inferred from Sequence Orthology more info
involved_in intestinal absorption	ISO Inferred from Sequence Orthology more info
involved_in intracellular pH elevation	ISO Inferred from Sequence Orthology more info
involved_in mannitol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in oxalate transport	ISO Inferred from Sequence Orthology more info
involved_in oxalic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dipeptide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in protein kinase C signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular pH	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial chloride transport	ISO Inferred from Sequence Orthology more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: solute carrier family 26 member 6

Names: solute carrier family 26 (anion exchanger), member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143817.1 → NP_001137289.1 solute carrier family 26 member 6

See identical proteins and their annotated locations for NP_001137289.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A8I6AS58, A6I392, D3Z9I5

Conserved Domains (3) summary

cd07042
Location:653 → 734

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:78 → 737

sulP; high affinity sulphate transporter 1

cl23746
Location:369 → 452

HCO3_cotransp; HCO3- transporter family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

118438110..118448271

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243757.5 → XP_006243819.1 solute carrier family 26 member 6 isoform X2

UniProtKB/TrEMBL

A0A8I6AS58

Related

ENSRNOP00000095796.1, ENSRNOT00000114709.2

Conserved Domains (3) summary

cd07042
Location:532 → 703

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:78 → 706

sulP; high affinity sulphate transporter 1

cl23746
Location:369 → 452

HCO3_cotransp; HCO3- transporter family
XM_006243758.5 → XP_006243820.1 solute carrier family 26 member 6 isoform X3

UniProtKB/TrEMBL

A0A8I6AS58

Conserved Domains (3) summary

pfam00916
Location:102 → 481

Sulfate_transp; Sulfate permease family

cl00604
Location:532 → 569

STAS; Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors

cl23746
Location:369 → 452

HCO3_cotransp; HCO3- transporter family
XM_006243756.5 → XP_006243818.1 solute carrier family 26 member 6 isoform X1

See identical proteins and their annotated locations for XP_006243818.1

UniProtKB/TrEMBL

A0A8I6AS58, A6I393

Related

ENSRNOP00000027762.6, ENSRNOT00000027762.9

Conserved Domains (1) summary

TIGR00815
Location:55 → 714

sulP; high affinity sulphate transporter 1
XM_006243755.5 → XP_006243817.1 solute carrier family 26 member 6 isoform X1

See identical proteins and their annotated locations for XP_006243817.1

UniProtKB/TrEMBL

A0A8I6AS58, A6I393

Conserved Domains (1) summary

TIGR00815
Location:55 → 714

sulP; high affinity sulphate transporter 1
XM_063265256.1 → XP_063121326.1 solute carrier family 26 member 6 isoform X4