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    B4galt7 beta-1,4-galactosyltransferase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    B4galt7provided by RGD
    Official Full Name
    beta-1,4-galactosyltransferase 7provided by RGD
    Primary source
    RGD:1309214
    See related
    EnsemblRapid:ENSRNOG00000021886 AllianceGenome:RGD:1309214
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; manganese ion binding activity; and xylosylprotein 4-beta-galactosyltransferase activity. Predicted to be involved in several processes, including glycoprotein biosynthetic process; glycosaminoglycan biosynthetic process; and negative regulation of fibroblast proliferation. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 1. Orthologous to human B4GALT7 (beta-1,4-galactosyltransferase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 45.6), Muscle (RPKM 44.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See B4galt7 in Genome Data Viewer
    Location:
    17p14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (9023667..9032742, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9018514..9027591, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9549605..9558672, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 46 Neighboring gene transfer RNA serine (anticodon AGA) 29 Neighboring gene calcium modulating ligand Neighboring gene transmembrane p24 trafficking protein 9 Neighboring gene family with sequence similarity 193, member B Neighboring gene uncharacterized LOC108348505

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of β-1,4-galactosyltransferase 7 enzyme reveal conformational changes and substrate binding. Tsutsui Y, et al. J Biol Chem, 2013 Nov 1. PMID 24052259, Free PMC Article
    2. Molecular basis for the progeroid variant of Ehlers-Danlos syndrome. Identification and characterization of two mutations in galactosyltransferase I gene. Okajima T, et al. J Biol Chem, 1999 Oct 8. PMID 10506123
    3. Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene family. Almeida R, et al. J Biol Chem, 1999 Sep 10. PMID 10473568
    4. Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). Seidler DG, et al. J Mol Med (Berl), 2006 Jul. PMID 16583246
    5. Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans. Okajima T, et al. J Biol Chem, 1999 Aug 13. PMID 10438455

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC116242

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables xylosylprotein 4-beta-galactosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xylosylprotein 4-beta-galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycosaminoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in supramolecular fiber organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-1,4-galactosyltransferase 7
    Names
    xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7
    xylosylprotein beta1,4-galactosyltransferase, polypeptide 7 (galactosyltransferase I)
    NP_001026831.1
    XP_008769723.1
    XP_038951894.1
    XP_063132733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031661.1 → NP_001026831.1  beta-1,4-galactosyltransferase 7

      See identical proteins and their annotated locations for NP_001026831.1

      Status: PROVISIONAL

      Source sequence(s)
      BC099103
      UniProtKB/TrEMBL
      F7ETN7, Q4FZU7
      Related
      ENSRNOP00000029002.5, ENSRNOT00000036223.6
      Conserved Domains (1) summary
      cd00899
      Location:92 → 315
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      9023667..9032742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008771501.4 → XP_008769723.1  beta-1,4-galactosyltransferase 7 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C0, F7ETN7
      Related
      ENSRNOP00000072981.1, ENSRNOT00000083492.3
      Conserved Domains (1) summary
      cd00899
      Location:146 → 369
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    2. XM_039095966.2 → XP_038951894.1  beta-1,4-galactosyltransferase 7 isoform X3

      Conserved Domains (1) summary
      cd00899
      Location:1 → 201
      b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

    3. XM_063276663.1 → XP_063132733.1  beta-1,4-galactosyltransferase 7 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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