Cxcl11 C-X-C motif chemokine ligand 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cxcl11provided by RGD
Official Full Name: C-X-C motif chemokine ligand 11provided by RGD
Primary source: RGD:727827
See related: EnsemblRapid:ENSRNOG00000022298 AllianceGenome:RGD:727827
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SCYB11
Summary: Enables chemokine activity. Involved in immune response. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of interstitial cystitis. Orthologous to human CXCL11 (C-X-C motif chemokine ligand 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 105.6), Heart (RPKM 104.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (15973728..15976503)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (15689432..15692207)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17195395..17198170)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that, like the other CXCR3 chemokines, rat CXCL11 seems to have a role in the homing of CD4(+) T cells in both acute and chronic rejection models of heart allotransplantation.
Title: Rat chemokine CXCL11: structure, tissue distribution, function and expression in cardiac transplantation models.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CXCR3 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables chemokine activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chemokine activity	ISO Inferred from Sequence Orthology more info
enables chemokine receptor binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in chemokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: C-X-C motif chemokine 11

Names: chemokine (C-X-C motif) ligand 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182952.2 → NP_891997.1 C-X-C motif chemokine 11 precursor

See identical proteins and their annotated locations for NP_891997.1

Status: PROVISIONAL

Source sequence(s)

AF537209

UniProtKB/TrEMBL

B5DEM2, Q7TNL0

Related

ENSRNOP00000035380.3, ENSRNOT00000031667.6

Conserved Domains (1) summary

cd00273
Location:28 → 91

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...