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    Cul9 cullin 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316228, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cul9provided by RGD
    Official Full Name
    cullin 9provided by RGD
    Primary source
    RGD:1562008
    See related
    EnsemblRapid:ENSRNOG00000018372 AllianceGenome:RGD:1562008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Parc; RGD1562008
    Summary
    Predicted to enable transferase activity; ubiquitin protein ligase binding activity; and zinc ion binding activity. Predicted to be involved in microtubule cytoskeleton organization; protein ubiquitination; and regulation of mitotic nuclear division. Predicted to be located in cytosol. Predicted to be part of cullin-RING ubiquitin ligase complex. Orthologous to human CUL9 (cullin 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 42.7), Brain (RPKM 41.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cul9 in Genome Data Viewer
    Location:
    9q12
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (21933699..21977145)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14435948..14479552)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (16747449..16844033)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094784 Neighboring gene serum response factor Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Li Z, et al. Mol Cell, 2014 Jun 5. PMID 24793696, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cullin-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cullin-9
    Names
    p53-associated parkin-like cytoplasmic protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191582.4 → NP_001178511.2  cullin-9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      Conserved Domains (8) summary
      smart00647
      Location:2134 → 2196
      IBR; In Between Ring fingers
      cd00162
      Location:2063 → 2113
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl02148
      Location:1159 → 1289
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1585 → 1804
      Cullin; Cullin family
      pfam01485
      Location:2227 → 2262
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366 → 440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1856 → 1936
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:2062 → 2113
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      21933699..21977145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083508.2 → XP_038939436.1  cullin-9 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K652
      Related
      ENSRNOP00000073679.2, ENSRNOT00000080815.3
      Conserved Domains (8) summary
      smart00647
      Location:2162 → 2224
      IBR; In Between Ring fingers
      cd00162
      Location:2091 → 2141
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl02148
      Location:1159 → 1289
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1585 → 1832
      Cullin; Cullin family
      pfam01485
      Location:2255 → 2290
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366 → 440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1884 → 1964
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:2090 → 2141
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_039083509.2 → XP_038939437.1  cullin-9 isoform X2

      Conserved Domains (8) summary
      smart00647
      Location:2162 → 2224
      IBR; In Between Ring fingers
      cd00162
      Location:2091 → 2141
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl02148
      Location:1159 → 1289
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1585 → 1832
      Cullin; Cullin family
      pfam01485
      Location:2255 → 2290
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366 → 440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1884 → 1964
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:2090 → 2141
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    3. XM_039083510.2 → XP_038939438.1  cullin-9 isoform X3

      Related
      ENSRNOP00000104760.1, ENSRNOT00000164147.1
      Conserved Domains (7) summary
      cd00162
      Location:2091 → 2141
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl02148
      Location:1159 → 1289
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1585 → 1832
      Cullin; Cullin family
      pfam01485
      Location:2162 → 2213
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:366 → 440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1884 → 1964
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:2090 → 2141
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    4. XM_063267094.1 → XP_063123164.1  cullin-9 isoform X4

    5. XM_039083512.2 → XP_038939440.1  cullin-9 isoform X6

      Conserved Domains (5) summary
      cl02148
      Location:1159 → 1289
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1585 → 1832
      Cullin; Cullin family
      pfam11515
      Location:366 → 440
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1884 → 1964
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:2090 → 2115
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    6. XM_039083511.2 → XP_038939439.1  cullin-9 isoform X5

      Conserved Domains (8) summary
      smart00647
      Location:1945 → 2007
      IBR; In Between Ring fingers
      cd00162
      Location:1874 → 1924
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl02148
      Location:942 → 1072
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
      pfam00888
      Location:1368 → 1615
      Cullin; Cullin family
      pfam01485
      Location:2038 → 2073
      IBR; IBR domain, a half RING-finger domain
      pfam11515
      Location:149 → 223
      Cul7; Mouse development and cellular proliferation protein Cullin-7
      cl11186
      Location:1667 → 1747
      Cullin_Nedd8; Cullin protein neddylation domain
      cl17238
      Location:1873 → 1924
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_005488890.2 RNA Sequence

    2. XR_005488889.2 RNA Sequence

    3. XR_010054591.1 RNA Sequence

    4. XR_005488891.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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