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    Fbxo15 F-box protein 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361354, updated on 9-Dec-2024

    Summary

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    Symbol
    Fbxo15provided by RGD
    Full Name
    F-box protein 15provided by RGD
    Primary source
    RGD:1310628
    See related
    EnsemblRapid:ENSRNOG00000038225 AllianceGenome:RGD:1310628
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO15 (F-box protein 15). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 43.3), Testes (RPKM 30.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxo15 in Genome Data Viewer
    Location:
    18q12.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80594444..80909549)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (78319577..78634695)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81785408..81882796)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482966 Neighboring gene polyglutamine binding protein 1, pseudogene 1 Neighboring gene uncharacterized LOC134482968 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene rho-related GTP-binding protein RhoG-like Neighboring gene ATP binding cassette subfamily G member 2, pseudogene 1 Neighboring gene neuropilin and tolloid like 1 Neighboring gene enolase 1, pseudogene 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
    2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395752.1 → NP_001382681.1  F-box only protein 15

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      D3Z8N7
      Related
      ENSRNOP00000055000.7, ENSRNOT00000058199.7
      Conserved Domains (1) summary
      smart00256
      Location:81 → 121
      FBOX; A Receptor for Ubiquitination Targets

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      80594444..80909549
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096992.2 → XP_038952920.1  F-box only protein 15 isoform X1

      UniProtKB/TrEMBL
      D3Z8N7
      Conserved Domains (1) summary
      pfam12937
      Location:92 → 136
      F-box-like

    2. XM_039096994.2 → XP_038952922.1  F-box only protein 15 isoform X3

      Conserved Domains (1) summary
      pfam12937
      Location:140 → 184
      F-box-like

    3. XM_039096998.2 → XP_038952926.1  F-box only protein 15 isoform X7

      Conserved Domains (1) summary
      pfam12937
      Location:140 → 184
      F-box-like

    4. XM_039096993.2 → XP_038952921.1  F-box only protein 15 isoform X2

      Conserved Domains (1) summary
      pfam12937
      Location:140 → 184
      F-box-like

    5. XM_063277485.1 → XP_063133555.1  F-box only protein 15 isoform X4

    6. XM_039096997.2 → XP_038952925.1  F-box only protein 15 isoform X6

      Conserved Domains (1) summary
      pfam12937
      Location:140 → 184
      F-box-like

    7. XM_039096996.2 → XP_038952924.1  F-box only protein 15 isoform X5

      UniProtKB/TrEMBL
      A6K5M6
      Related
      ENSRNOP00000098243.2, ENSRNOT00000120608.2
      Conserved Domains (1) summary
      pfam12937
      Location:2 → 42
      F-box-like

    8. XM_039096995.2 → XP_038952923.1  F-box only protein 15 isoform X5

      UniProtKB/TrEMBL
      A6K5M6
      Conserved Domains (1) summary
      pfam12937
      Location:2 → 42
      F-box-like

    9. XM_063277486.1 → XP_063133556.1  F-box only protein 15 isoform X8

      UniProtKB/TrEMBL
      M0RD43

    RNA

    1. XR_005496060.2 RNA Sequence

    2. XR_005496061.2 RNA Sequence

    3. XR_005496062.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108436.1: Suppressed sequence

      Description
      NM_001108436.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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