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    Hscb HscB mitochondrial iron-sulfur cluster co-chaperone [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hscbprovided by RGD
    Official Full Name
    HscB mitochondrial iron-sulfur cluster co-chaperoneprovided by RGD
    Primary source
    RGD:1311005
    See related
    EnsemblRapid:ENSRNOG00000037508 AllianceGenome:RGD:1311005
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311005
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in [2Fe-2S] cluster assembly and primitive erythrocyte differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Orthologous to human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 134.6), Spleen (RPKM 128.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hscb in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51481318..51491689)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45821527..45831902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51878267..51888645)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC120096015 Neighboring gene checkpoint kinase 2 Neighboring gene uncharacterized LOC120096017 Neighboring gene unc-51 like autophagy activating kinase 1 Neighboring gene pseudouridine synthase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis. Uhrigshardt H, et al. Hum Mol Genet, 2010 Oct 1. PMID 20668094, Free PMC Article
    2. Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery. Maio N, et al. Cell Metab, 2014 Mar 4. PMID 24606901, Free PMC Article
    3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in [2Fe-2S] cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primitive hemopoiesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein complex oligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    iron-sulfur cluster co-chaperone protein HscB
    Names
    HscB iron-sulfur cluster co-chaperone homolog
    iron-sulfur cluster co-chaperone protein HscB, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108340.1 → NP_001101810.1  iron-sulfur cluster co-chaperone protein HscB precursor

      See identical proteins and their annotated locations for NP_001101810.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A6J288, D3ZME7
      Related
      ENSRNOP00000053641.2, ENSRNOT00000056798.5
      Conserved Domains (2) summary
      PRK03578
      Location:67 → 227
      hscB; Fe-S protein assembly co-chaperone HscB
      pfam18256
      Location:38 → 64
      HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      51481318..51491689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769340.3 → XP_008767562.1  iron-sulfur cluster co-chaperone protein HscB isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2K9
      Related
      ENSRNOP00000085570.2, ENSRNOT00000102335.2
      Conserved Domains (3) summary
      PRK03578
      Location:67 → 189
      hscB; co-chaperone HscB; Provisional
      pfam07743
      Location:157 → 189
      HSCB_C; HSCB C-terminal oligomerization domain
      pfam16919
      Location:40 → 60
      PknG_rubred; Protein kinase G rubredoxin domain

    2. XM_006249564.4 → XP_006249626.1  iron-sulfur cluster co-chaperone protein HscB isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZYF5
      Related
      ENSRNOP00000101643.1, ENSRNOT00000162294.1
      Conserved Domains (3) summary
      PRK03578
      Location:67 → 211
      hscB; co-chaperone HscB; Provisional
      pfam07743
      Location:157 → 212
      HSCB_C; HSCB C-terminal oligomerization domain
      pfam16919
      Location:40 → 60
      PknG_rubred; Protein kinase G rubredoxin domain

    3. XM_039089617.2 → XP_038945545.1  iron-sulfur cluster co-chaperone protein HscB isoform X4

      UniProtKB/TrEMBL
      A6J289
      Conserved Domains (2) summary
      PRK03578
      Location:67 → 141
      hscB; Fe-S protein assembly co-chaperone HscB
      pfam18256
      Location:38 → 64
      HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

    4. XM_039089618.2 → XP_038945546.1  iron-sulfur cluster co-chaperone protein HscB isoform X6

      Conserved Domains (2) summary
      PRK03578
      Location:67 → 142
      hscB; Fe-S protein assembly co-chaperone HscB
      pfam18256
      Location:38 → 64
      HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

    5. XM_039089616.2 → XP_038945544.1  iron-sulfur cluster co-chaperone protein HscB isoform X3

      Conserved Domains (2) summary
      PRK03578
      Location:67 → 142
      hscB; Fe-S protein assembly co-chaperone HscB
      pfam18256
      Location:38 → 64
      HscB_4_cys; Co-chaperone HscB tetracysteine metal binding motif

    6. XM_063271547.1 → XP_063127617.1  iron-sulfur cluster co-chaperone protein HscB isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version

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