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    Gpt2 glutamic--pyruvic transaminase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307759, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpt2provided by RGD
    Official Full Name
    glutamic--pyruvic transaminase 2provided by RGD
    Primary source
    RGD:1305462
    See related
    EnsemblRapid:ENSRNOG00000059579 AllianceGenome:RGD:1305462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ALT2; Cc2-5
    Summary
    Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Involved in several processes, including cellular response to insulin stimulus; gluconeogenesis; and response to testosterone. Located in extracellular space. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 312.5), Liver (RPKM 220.8) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpt2 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37700023..37734551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21526800..21561314, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (22599003..22633529, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene neuropilin and tolloid like 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2 Neighboring gene uncharacterized LOC102548349 Neighboring gene uncharacterized LOC120098665 Neighboring gene similar to human chromosome 16 open reading frame 87

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Alanine aminotransferase regulation by androgens in non-hepatic tissues. Coss CC, et al. Pharm Res, 2012 Apr. PMID 22167351
    2. Isoform-specific alanine aminotransferase measurement can distinguish hepatic from extrahepatic injury in humans. Rafter I, et al. Int J Mol Med, 2012 Nov. PMID 22922605
    3. Alanine aminotransferase isoenzymes: molecular cloning and quantitative analysis of tissue expression in rats and serum elevation in liver toxicity. Yang RZ, et al. Hepatology, 2009 Feb. PMID 19085960, Free PMC Article
    4. Increased hepatic expression is a major determinant of serum alanine aminotransferase elevation in mice with nonalcoholic steatohepatitis. Liu R, et al. Liver Int, 2009 Mar. PMID 18710424
    5. Hepatic ALT isoenzymes are elevated in gluconeogenic conditions including diabetes and suppressed by insulin at the protein level. Qian K, et al. Diabetes Metab Res Rev, 2015 Sep. PMID 25865565, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-alanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-alanine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to insulin stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in gluconeogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to testosterone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alanine aminotransferase 2
    Names
    glutamic pyruvate transaminase (alanine aminotransferase) 2
    NP_001012057.1
    XP_008770627.1
    XP_008770628.1
    XP_063134088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012057.2 → NP_001012057.1  alanine aminotransferase 2

      See identical proteins and their annotated locations for NP_001012057.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6ACI1, A0A8I6ARL0, A6KDD7
      Related
      ENSRNOP00000090767.1, ENSRNOT00000099582.2
      Conserved Domains (2) summary
      cd00609
      Location:123 → 512
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:48 → 522
      PTZ00377; alanine aminotransferase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      37700023..37734551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772406.4 → XP_008770628.1  alanine aminotransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_008770628.1

      UniProtKB/TrEMBL
      A0A8I6ACI1, A0A8I6ARL0, A6KDD7
      Conserved Domains (2) summary
      cd00609
      Location:123 → 512
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:48 → 522
      PTZ00377; alanine aminotransferase; Provisional

    2. XM_063278018.1 → XP_063134088.1  alanine aminotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACI1, A0A8I6ARL0, A6KDD7
      Related
      ENSRNOP00000069387.2, ENSRNOT00000077275.3

    3. XM_008772405.4 → XP_008770627.1  alanine aminotransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_008770627.1

      UniProtKB/TrEMBL
      A0A8I6ACI1, A0A8I6ARL0, A6KDD7
      Conserved Domains (2) summary
      cd00609
      Location:123 → 512
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:48 → 522
      PTZ00377; alanine aminotransferase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version

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