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    Asap3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684122, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Asap3provided by RGD
    Official Full Name
    ArfGAP with SH3 domain, ankyrin repeat and PH domain 3provided by RGD
    Primary source
    RGD:1593929
    See related
    EnsemblRapid:ENSRNOG00000049714 AllianceGenome:RGD:1593929
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in cell migration; positive regulation of GTPase activity; and regulation of stress fiber assembly. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in focal adhesion; intracellular membrane-bounded organelle; and ruffle. Orthologous to human ASAP3 (ArfGAP with SH3 domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 56.8), Liver (RPKM 52.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Asap3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153716988..153757787)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148433382..148476027)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154551901..154596125)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene inhibitor of DNA binding 3 Neighboring gene uncharacterized LOC134479041 Neighboring gene E2F transcription factor 2 Neighboring gene uncharacterized LOC134487016 Neighboring gene transcription elongation factor A3 Neighboring gene immunoglobulin heavy chain 6 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of ASAP3 contributes to colorectal carcinogenesis and indicates poor survival outcome. Tian H, et al. Cancer Sci, 2017 Aug. PMID 28502111, Free PMC Article
    2. ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. Ha VL, et al. J Biol Chem, 2008 May 30. PMID 18400762, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stress fiber assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ruffle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427661.1 → NP_001414590.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6ITA3, M0R5J1
      Related
      ENSRNOP00000064660.4, ENSRNOT00000072864.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      153716988..153757787
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111294.2 → XP_038967222.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A6ITA3
      Related
      ENSRNOP00000101576.1, ENSRNOT00000148151.1
      Conserved Domains (5) summary
      cd07640
      Location:21 → 221
      BAR_ASAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 3
      cd13251
      Location:272 → 378
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:528 → 561
      ANK; ANK repeat [structural motif]
      cd17900
      Location:401 → 521
      ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
      pfam12796
      Location:567 → 652
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039111295.2 → XP_038967223.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2

      Conserved Domains (4) summary
      cd13251
      Location:21 → 127
      PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
      sd00045
      Location:277 → 310
      ANK; ANK repeat [structural motif]
      cd17900
      Location:150 → 270
      ArfGap_ASAP3; ArfGAP domain of ASAP3 (ArfGAP with ANK repeat and PH domain-containing protein 3)
      pfam12796
      Location:316 → 401
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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