Best2 bestrophin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Best2provided by RGD
Official Full Name: bestrophin 2provided by RGD
Primary source: RGD:1305377
See related: EnsemblRapid:ENSRNOG00000003737 AllianceGenome:RGD:1305377
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vmd2l1
Summary: Predicted to enable bicarbonate channel activity; intracellularly ligand-gated monoatomic ion channel activity; and ligand-gated monoatomic cation channel activity. Predicted to contribute to chloride channel activity. Predicted to be involved in bicarbonate transport; membrane depolarization; and sensory perception of smell. Predicted to act upstream of or within chloride transmembrane transport. Predicted to be located in basolateral plasma membrane and cilium. Predicted to be part of chloride channel complex. Orthologous to human BEST2 (bestrophin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 2.2), Thymus (RPKM 0.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40047191..40053216)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23142324..23148351)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26122869..26129619, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA levels for bestrophin-1 and -2 were also significantly reduced by bestrophin-3 down-regulation
Title: Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate channel activity	ISO Inferred from Sequence Orthology more info
contributes_to chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables intracellularly ligand-gated monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	ISO Inferred from Sequence Orthology more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chloride transport	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of chloride channel complex	ISO Inferred from Sequence Orthology more info
located_in cilium	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bestrophin-2

Names: vitelliform macular dystrophy 2-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396105.1 → NP_001383034.1 bestrophin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IY40, D4A3A7

Related

ENSRNOP00000061719.2, ENSRNOT00000067600.4

Conserved Domains (1) summary

pfam01062
Location:8 → 316

Bestrophin; RFP-TM, chloride channel