Bbx BBX high mobility group box domain containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Bbxprovided by RGD
Full Name: BBX high mobility group box domain containingprovided by RGD
Primary source: RGD:1309769
See related: EnsemblRapid:ENSRNOG00000001971 AllianceGenome:RGD:1309769
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within bone development. Predicted to be active in nucleus. Orthologous to human BBX (BBX high mobility group box domain containing). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 228.3), Adrenal (RPKM 142.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (63850034..64097700)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (50381249..50628934)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (52983286..53228557)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that loss of BBX induces apoptosis of postmeiotic spermatids and results in spermiogenesis defects and infertility.
Title: PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility.

Submit: New GeneRIF Correction

General gene information

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Markers

AU029174 (e-PCR)
- UniSTS:111630

AU025695 (e-PCR)
- UniSTS:115011

BBX (e-PCR)
- UniSTS:278098

BE114078 (e-PCR)
- UniSTS:247400

STS-N31990 (e-PCR)
- UniSTS:79213

RH138485 (e-PCR)
- UniSTS:220572

AU026904 (e-PCR)
- UniSTS:113821

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within bone development	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: HMG box transcription factor BBX

Names: BBX, HMG-box containing; HMG box transcription factor BBX-like; bobby sox homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079938.1 → NP_001073407.1 HMG box transcription factor BBX

See identical proteins and their annotated locations for NP_001073407.1

Status: PROVISIONAL

Source sequence(s)

BC129113

UniProtKB/TrEMBL

A1L1L0, A6IQT5

Related

ENSRNOP00000002700.5, ENSRNOT00000002700.8

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam09667
Location:191 → 302

DUF2028; Domain of unknown function (DUF2028)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

63850034..64097700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088363.2 → XP_038944291.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270545.1 → XP_063126615.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_063270541.1 → XP_063126611.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270544.1 → XP_063126614.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_063270557.1 → XP_063126627.1 HMG box transcription factor BBX isoform X6

UniProtKB/TrEMBL

A6IQT5
XM_063270552.1 → XP_063126622.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_063270558.1 → XP_063126628.1 HMG box transcription factor BBX isoform X7

UniProtKB/TrEMBL

A6IQT5

Related

ENSRNOP00000089981.2, ENSRNOT00000119802.2
XM_008768637.4 → XP_008766859.1 HMG box transcription factor BBX isoform X1

See identical proteins and their annotated locations for XP_008766859.1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_039088366.2 → XP_038944294.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6

Conserved Domains (2) summary

cd01388
Location:54 → 112

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:153 → 285

DUF2028; Domain of unknown function (DUF2028)
XM_017598008.3 → XP_017453497.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_008768634.4 → XP_008766856.1 HMG box transcription factor BBX isoform X1

See identical proteins and their annotated locations for XP_008766856.1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_039088365.2 → XP_038944293.1 HMG box transcription factor BBX isoform X2

UniProtKB/TrEMBL

A0A8I5ZRG6

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_008768638.4 → XP_008766860.1 HMG box transcription factor BBX isoform X3

See identical proteins and their annotated locations for XP_008766860.1

UniProtKB/TrEMBL

A1L1L0, A6IQT5

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam09667
Location:191 → 302

DUF2028; Domain of unknown function (DUF2028)
XM_008768641.4 → XP_008766863.1 HMG box transcription factor BBX isoform X5

UniProtKB/TrEMBL

A0A0G2JXW5, A6IQT5

Related

ENSRNOP00000070428.2, ENSRNOT00000083438.3

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; SOX-TCF_HMG-box, class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and ...

pfam09667
Location:191 → 302

DUF2028; Domain of unknown function (DUF2028)
XM_008768640.4 → XP_008766862.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6

Conserved Domains (2) summary

cd01388
Location:54 → 112

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:153 → 285

DUF2028; Domain of unknown function (DUF2028)
XM_063270535.1 → XP_063126605.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270536.1 → XP_063126606.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270553.1 → XP_063126623.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_063270537.1 → XP_063126607.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_017598001.3 → XP_017453490.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270549.1 → XP_063126619.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_063270539.1 → XP_063126609.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_017598004.3 → XP_017453493.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270550.1 → XP_063126620.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_017598002.3 → XP_017453491.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270543.1 → XP_063126613.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_063270551.1 → XP_063126621.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_063270538.1 → XP_063126608.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270556.1 → XP_063126626.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_063270534.1 → XP_063126604.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_017598003.3 → XP_017453492.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_017598005.3 → XP_017453494.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270554.1 → XP_063126624.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6
XM_017598007.3 → XP_017453496.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_017598009.3 → XP_017453498.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270548.1 → XP_063126618.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_039088364.2 → XP_038944292.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4

Conserved Domains (2) summary

cd01388
Location:79 → 150

SOX-TCF_HMG-box; class I member of the HMG-box superfamily of DNA-binding proteins. These proteins contain a single HMG box, and bind the minor groove of DNA in a highly sequence-specific manner. Members include SRY and its homologs in insects and vertebrates, and ...

pfam09667
Location:191 → 323

DUF2028; Domain of unknown function (DUF2028)
XM_063270542.1 → XP_063126612.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270540.1 → XP_063126610.1 HMG box transcription factor BBX isoform X1

UniProtKB/TrEMBL

A0A8I5ZRG6, A0A8I6ADK4
XM_063270547.1 → XP_063126617.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_063270546.1 → XP_063126616.1 HMG box transcription factor BBX isoform X3

UniProtKB/TrEMBL

A1L1L0, A6IQT5
XM_063270555.1 → XP_063126625.1 HMG box transcription factor BBX isoform X4

UniProtKB/TrEMBL

A0A8I5ZRG6