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    Gtf2h2 general transcription factor IIH subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294693, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2h2provided by RGD
    Official Full Name
    general transcription factor IIH subunit 2provided by RGD
    Primary source
    RGD:1310499
    See related
    EnsemblRapid:ENSRNOG00000018230 AllianceGenome:RGD:1310499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    BTF2 p44
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in several processes, including G protein-coupled receptor internalization; nucleotide-excision repair; and transcription initiation at RNA polymerase II promoter. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 68.4), Thymus (RPKM 68.4) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf2h2 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33358863..33386726, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31623752..31652697, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30494718..30522716, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene survival of motor neuron 1, telomeric Neighboring gene NLR family, apoptosis inhibitory protein 6 Neighboring gene NLR family, apoptosis inhibitory protein 5 Neighboring gene ribosomal protein eL22-like 1 Neighboring gene occludin Neighboring gene RNA, U4 small nuclear 64

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of XPC: implications in cancer and oxidative DNA damage. Melis JP, et al. Mutat Res, 2011 Nov-Dec. PMID 21763452, Free PMC Article
    2. A history of TFIIH: two decades of molecular biology on a pivotal transcription/repair factor. Egly JM, et al. DNA Repair (Amst), 2011 Jul 15. PMID 21592869
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of core TFIIH complex portion of holo TFIIH complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of core TFIIH complex portion of holo TFIIH complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH core complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIH holo complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIH holo complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIH holo complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor IIH subunit 2
    Names
    BTF2-p44
    TFIIH basal transcription factor complex p44 subunit
    basic transcription factor 2 44 kDa subunit
    general transcription factor IIH, polypeptide 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077428.1 → NP_001070896.1  general transcription factor IIH subunit 2

      See identical proteins and their annotated locations for NP_001070896.1

      Status: PROVISIONAL

      Source sequence(s)
      BC126097
      UniProtKB/Swiss-Prot
      A0JN27
      UniProtKB/TrEMBL
      A6I592
      Related
      ENSRNOP00000057895.2, ENSRNOT00000061183.5
      Conserved Domains (2) summary
      COG5151
      Location:11 → 386
      SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
      cd01453
      Location:56 → 240
      vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33358863..33386726 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231844.5 → XP_006231906.1  general transcription factor IIH subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006231906.1

      UniProtKB/Swiss-Prot
      A0JN27
      UniProtKB/TrEMBL
      A6I592
      Conserved Domains (2) summary
      COG5151
      Location:11 → 386
      SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
      cd01453
      Location:56 → 240
      vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

    2. XM_006231845.5 → XP_006231907.1  general transcription factor IIH subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006231907.1

      UniProtKB/Swiss-Prot
      A0JN27
      UniProtKB/TrEMBL
      A6I592
      Conserved Domains (2) summary
      COG5151
      Location:11 → 386
      SSL1; RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 [Transcription / DNA replication, recombination, and repair]
      cd01453
      Location:56 → 240
      vWA_transcription_factor_IIH_type; Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins ...

    3. XM_063281499.1 → XP_063137569.1  general transcription factor IIH subunit 2 isoform X2

    RNA

    1. XR_005500254.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0JN27.1 GenPept UniProtKB/Swiss-Prot:A0JN27

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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