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    Sp2 Sp2 transcription factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303499, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sp2provided by RGD
    Official Full Name
    Sp2 transcription factorprovided by RGD
    Primary source
    RGD:1592078
    See related
    EnsemblRapid:ENSRNOG00000010492 AllianceGenome:RGD:1592078
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including embryonic organ development; fibroblast proliferation; and in utero embryonic development. Predicted to be located in nucleoplasm. Orthologous to human SP2 (Sp2 transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 27.4), Adrenal (RPKM 20.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sp2 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (82437024..82467583, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81940580..81970040, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84890930..84920886, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene proline rich 15-like Neighboring gene uncharacterized LOC102547955 Neighboring gene pyridoxamine 5'-phosphate oxidase Neighboring gene uncharacterized LOC108352124 Neighboring gene Sp6 transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional significance of Sp1, Sp2, and Sp3 transcription factors in regulation of the murine CTP:phosphocholine cytidylyltransferase alpha promoter. Bakovic M, et al. J Lipid Res, 2000 Apr. PMID 10744779
    2. Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia. Wegener A, et al. J Neurochem, 2017 Jan. PMID 27889927
    3. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts. Baur F, et al. PLoS One, 2010 Mar 8. PMID 20221402, Free PMC Article
    4. Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system. Hammer F, et al. Endocrinology, 2004 Feb. PMID 14576192
    5. Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. Sun JM, et al. J Biol Chem, 2007 Nov 9. PMID 17827154

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. that Sp2 has a minor effect on the differentiation of myelinating glia, and that glutamine-rich Sp proteins are not essential regulators of the process
      Title: Sp2 is the only glutamine-rich specificity protein with minor impact on development and differentiation in myelinating glia.
    2. Sp1, Sp2 and Sp4 transcription factors play a role in activating cholesterol desmolase gene transcription in the nervous system, and Ku antigen may further augment this activation
      Title: Transcriptional regulation of P450scc gene expression in the embryonic rodent nervous system.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within circulatory system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic organ development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor Sp2
    Names
    Trans-acting transcription factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399622.1 → NP_001386551.1  transcription factor Sp2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      B5DEH3
      Related
      ENSRNOP00000072347.1, ENSRNOT00000087322.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      82437024..82467583 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269117.1 → XP_063125187.1  transcription factor Sp2 isoform X1

      UniProtKB/TrEMBL
      D3ZSM5
      Related
      ENSRNOP00000110364.1, ENSRNOT00000155912.1

    2. XM_039086078.2 → XP_038942006.1  transcription factor Sp2 isoform X1

      UniProtKB/TrEMBL
      D3ZSM5
      Conserved Domains (4) summary
      sd00017
      Location:553 → 572
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:608 → 630
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:594 → 617
      zf-H2C2_2; Zinc-finger double domain
      cd22540
      Location:33 → 549
      SP2_N; N-terminal domain of transcription factor Specificity Protein (SP) 2

    3. XM_039086080.1 → XP_038942008.1  transcription factor Sp2 isoform X2

      Conserved Domains (4) summary
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain
      cd22540
      Location:4 → 520
      SP2_N; N-terminal domain of transcription factor Specificity Protein (SP) 2

    4. XM_039086079.1 → XP_038942007.1  transcription factor Sp2 isoform X2

      Related
      ENSRNOP00000059769.3, ENSRNOT00000068083.3
      Conserved Domains (4) summary
      sd00017
      Location:524 → 543
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:579 → 601
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:565 → 588
      zf-H2C2_2; Zinc-finger double domain
      cd22540
      Location:4 → 520
      SP2_N; N-terminal domain of transcription factor Specificity Protein (SP) 2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107045.1: Suppressed sequence

      Description
      NM_001107045.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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