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    Zfp212 Zinc finger protein 212 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297066, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zfp212provided by RGD
    Official Full Name
    Zinc finger protein 212provided by RGD
    Primary source
    RGD:1307836
    See related
    EnsemblRapid:ENSRNOG00000006711 AllianceGenome:RGD:1307836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including dendrite development; general adaptation syndrome, behavioral process; and walking behavior. Predicted to be located in nucleoplasm. Orthologous to human ZNF212 (zinc finger protein 212). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 120.9), Lung (RPKM 84.1) and 9 other tissues See more
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    Genomic context

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    See Zfp212 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (78254582..78267017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (76923638..76936076)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (77591880..77604307)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene zinc finger protein 282 Neighboring gene ATP synthase subunit delta, mitochondrial pseudogene Neighboring gene zinc finger protein 956 Neighboring gene zinc finger protein 783 Neighboring gene transfer RNA cysteine (anticodon GCA) 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Gao J, et al. Genomics, 2008 Apr. PMID 18255255
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within dendrite development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within general adaptation syndrome, behavioral process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to alcohol ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within walking behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 212

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100839.1 → NP_001094309.1  zinc finger protein 212

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6K0D6
      Related
      ENSRNOP00000009054.7, ENSRNOT00000009054.9
      Conserved Domains (4) summary
      cd07765
      Location:142 → 180
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:329 → 474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:426 → 446
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      78254582..78267017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236446.5 → XP_006236508.1  zinc finger protein 212 isoform X1

      See identical proteins and their annotated locations for XP_006236508.1

      UniProtKB/TrEMBL
      G3V6U6
      Conserved Domains (5) summary
      cd07765
      Location:142 → 180
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:318 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:425 → 445
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:437 → 462
      zf-H2C2_2; Zinc-finger double domain

    2. XM_039108653.2 → XP_038964581.1  zinc finger protein 212 isoform X2

      UniProtKB/TrEMBL
      Q52KK5
      Conserved Domains (4) summary
      cd07765
      Location:88 → 126
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:275 → 420
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:314 → 334
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:372 → 392
      zf-C2H2; Zinc finger, C2H2 type
    Nucleotide Protein Strain
    Heading Accession and Version

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