Ces1e carboxylesterase 1E [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Ces1eprovided by RGD
Full Name: carboxylesterase 1Eprovided by RGD
Primary source: RGD:621508
See related: EnsemblRapid:ENSRNOG00000071280 AllianceGenome:RGD:621508
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ces1; Es22
Summary: Enables retinyl-palmitate esterase activity. Predicted to be involved in lipid catabolic process. Located in intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 19p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (30006173..30042628)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (13833154..13869627)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

comparative analysis of CES1 and CES2 in liver and small intestine of humans, monkeys, dogs, rabbits and rats
Title: Carboxylesterase in the liver and small intestine of experimental animals and human.
results demonstrate elevation of FC and depletion of cholesteryl esters by over-expression of hncCEH, which were resistant to compensatory responses by other enzymes of cholesterol homeostasis
Title: Over-expression of hepatic neutral cytosolic cholesteryl ester hydrolase in mice increases free cholesterol and reduces expression of HMG-CoAR, CYP27, and CYP7A1.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables carboxylesterase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables carboxylic ester hydrolase activity	TAS Traceable Author Statement more info	PubMed
enables retinyl-palmitate esterase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carboxylesterase 1E

Names: ES-HTEL; carboxyesterase ES-3; carboxylesterase 1; egasyn; esterase 22; liver carboxylesterase 3; pI 5.5 esterase

NP_113753.2

EC 3.1.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031565.3 → NP_113753.2 carboxylesterase 1E precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q63108

UniProtKB/TrEMBL

A0A8I6AA76

Related

ENSRNOP00000098478.1, ENSRNOT00000120869.2

Conserved Domains (2) summary

COG0657
Location:43 → 239

Aes; Acetyl esterase/lipase [Lipid transport and metabolism]

pfam00135
Location:24 → 545

COesterase; Carboxylesterase family