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Grin2a glutamate ionotropic receptor NMDA type subunit 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24409, updated on 9-Dec-2024

Summary

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Official Symbol: Grin2aprovided by RGD
Official Full Name: glutamate ionotropic receptor NMDA type subunit 2Aprovided by RGD
Primary source: RGD:2737
See related: EnsemblRapid:ENSRNOG00000033942 AllianceGenome:RGD:2737
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NR2A; GluN2A; NMDAR2A
Summary: Enables several functions, including enzyme binding activity; glutamate binding activity; and monoatomic ion channel activity. Contributes to extracellularly glutamate-gated ion channel activity and monoatomic cation channel activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendrite; postsynaptic density, intracellular component; and postsynaptic membrane. Part of NMDA selective glutamate receptor complex. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Used to study hyperhomocysteinemia and transient cerebral ischemia. Biomarker of cognitive disorder; placental insufficiency; post-traumatic stress disorder; status epilepticus; and withdrawal disorder. Human ortholog(s) of this gene implicated in several diseases, including Huntington's disease; alcohol dependence; bipolar disorder; colorectal cancer; and heroin dependence. Orthologous to human GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 176.8) See more
Orthologs: human mouse all
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Genomic context

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See Grin2a in Genome Data Viewer

Location:: 10q11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (6136458..6560003)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (5629683..6053262)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (5707806..6123568)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GluN2A- and GluN2B-containing pre-synaptic N-methyl-d-aspartate receptors differentially regulate action potential-evoked Ca[2+] influx via modulation of SK channels.
Title: GluN2A- and GluN2B-containing pre-synaptic N-methyl-d-aspartate receptors differentially regulate action potential-evoked Ca(2+) influx via modulation of SK channels.
Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats.
Title: Differential expression of GluN2 NMDA receptor subunits in the dorsal horn of male and female rats.
Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity.
Title: Homocysteine-induced sustained GluN2A NMDA receptor stimulation leads to mitochondrial ROS generation and neurotoxicity.
GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization.
Title: GluN2A Mediates PS-Induced Depressive-Like Behavior by Activating CaMKII and Inhibiting Myelinization.
RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Title: RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG.
Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIalpha phosphorylation of the GluN2A subunit.
Title: Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit.
Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex.
Title: Differential effects of memory enhancing and impairing doses of methylphenidate on serotonin metabolism and 5-HT1A, GABA, glutamate receptor expression in the rat prefrontal cortex.
Knockdown of astrocytic Grin2a aggravates beta-amyloid-induced memory and cognitive deficits through regulating nerve growth factor.
Title: Knockdown of astrocytic Grin2a aggravates β-amyloid-induced memory and cognitive deficits through regulating nerve growth factor.
Disrupting the alpha7nAChR-NR2A protein complex exerts antidepressant-like effects.
Title: Disrupting the α7nAChR-NR2A protein complex exerts antidepressant-like effects.
The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures.
Title: The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures.

Submit: New GeneRIF Correction See all GeneRIFs (167)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE120369 (e-PCR)
- UniSTS:247315

D10Got164 (e-PCR)
- UniSTS:115280

Grin2a (e-PCR), detects polymorphism
- UniSTS:143261

BF413021 (e-PCR)
- UniSTS:248486

ha2303 (e-PCR)
- UniSTS:515519

D10Ulb1 (e-PCR)
- UniSTS:518612

D10Got9 (e-PCR)
- UniSTS:111854

D10Got12 (e-PCR)
- UniSTS:114421

Grin2a (e-PCR), detects polymorphism
- UniSTS:531448

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables NMDA glutamate receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables NMDA glutamate receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to extracellularly glutamate-gated ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate binding	IDA Inferred from Direct Assay more info	PubMed
enables glutamate binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables glutamate-gated calcium ion channel activity	IEA Inferred from Electronic Annotation more info
enables glutamate-gated calcium ion channel activity	ISO Inferred from Sequence Orthology more info
enables glutamate-gated calcium ion channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to glutamate-gated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate-gated receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	EXP Inferred from Experiment more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic cation channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auditory behavior	IEP Inferred from Expression Pattern more info	PubMed
involved_in calcium ion transmembrane import into cytosol	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane import into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amino acid stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dsRNA	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glycine	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to magnesium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to zinc ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in conditioned place preference	IEP Inferred from Expression Pattern more info	PubMed
involved_in dendritic spine organization	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in directional locomotion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within directional locomotion	ISO Inferred from Sequence Orthology more info
involved_in dopamine metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotion	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in memory	IDA Inferred from Direct Assay more info	PubMed
involved_in memory	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in modulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in multicellular organismal response to stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter receptor transport, plasma membrane to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inhibitory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein targeting to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to postsynaptic membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to postsynaptic membrane	ISO Inferred from Sequence Orthology more info
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ARF protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of NMDA receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of long-term neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to amine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ammonium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to amphetamine	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cocaine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to environmental enrichment	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	ISO Inferred from Sequence Orthology more info
involved_in response to fungicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen sulfide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lead ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to manganese ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to methylmercury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to other organism	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in rhythmic process	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in serotonin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within serotonin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in sleep	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sleep	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	IEP Inferred from Expression Pattern more info	PubMed
involved_in startle response	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within startle response	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	TAS Traceable Author Statement more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2A

Names: N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; glutamate [NMDA] receptor subunit epsilon-1; glutamate receptor, ionotropic, N-methyl D-aspartate 2A

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012573.4 → NP_036705.3 glutamate receptor ionotropic, NMDA 2A precursor

See identical proteins and their annotated locations for NP_036705.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010, M91561

UniProtKB/Swiss-Prot

O08948, Q00959, Q63728

UniProtKB/TrEMBL

A6K4L3, G3V9C5

Related

ENSRNOP00000042235.4, ENSRNOT00000044626.5

Conserved Domains (5) summary

cd06378
Location:32 → 392

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

COG0834
Location:458 → 541

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13718
Location:403 → 802

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 828

Lig_chan; Ligand-gated ion channel

pfam10565
Location:839 → 1464

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus