Lilrb2 leukocyte immunoglobulin like receptor B2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lilrb2provided by RGD
Official Full Name: leukocyte immunoglobulin like receptor B2provided by RGD
Primary source: RGD:70895
See related: EnsemblRapid:ENSRNOG00000054954 AllianceGenome:RGD:70895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pirb; Nilr1; Lilrb3; NILR-1
Summary: Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRB1 (leukocyte immunoglobulin like receptor B1); LILRB2 (leukocyte immunoglobulin like receptor B2); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 43.3), Lung (RPKM 29.8) and 9 other tissues See more
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Genomic context

Location:: 1q12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (74242200..74250051)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (65326832..65334683)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (63734135..63741986)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electroacupuncture (EA) enhances rehabilitation against stroke by regulating epigenetic changes to directly act on its targets, such as the miR-181b/PirB/RhoA/GAP43 axis, which is a novel mechanism of EA therapy.
Title: Electroacupuncture enhances rehabilitation through miR-181b targeting PirB after ischemic stroke.
In the original motor cortical representations of the brachial plexus, mRNA and protein expression levels of MHCI, PirB, and CD3zeta were down-regulated 7 days post brachial plexus injury compared with control. Interestingly, mRNA and protein expression levels of these factors were up-regulated at 3 months compared with 7 days, excepting PirB protein, whose expression was not increasing.
Title: Changes in Expressions of Major Histocompatibility Complex Class I, Paired-Immunoglobulin-Like Receptor B, and Cluster of Differentiation 3ζ in Motor Cortical Representations of the Brachial Plexus After Avulsion in Rats.
Estradiol protects oligodendrocyte precursor cells from hyperoxiainduced apoptosis, predominantly through the downregulation of PirB.
Title: 17β-estradiol suppresses hyperoxia-induced apoptosis of oligodendrocytes through paired-immunoglobulin-like receptor B.
PirB might be involved in hypoxic-ischemic brain damage (HIBD) through a Rho-ROCK-dependent mechanism.
Title: [Neuroregeneration of newborn rats with hypoxic-ischemic brain damage following antibody-mediated neutralization of paired-immunoglobulin-like receptor B].
The expression level of PirB in the normal spinal cord was low. Expression was elevated in injured spinal cord.
Title: Expression of PirB in normal and injured spinal cord of rats.
Protein expression of major histocompatibity complex was elevated with aging in synaptosomes, hippocampal CA1, and dentate gyrus, while PirB protein expression was induced in both CA1 and DG.
Title: Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging.
PirB mRNA and protein expression increased in the cortical neurons of newborn rats following hypoxia-ischemia damage. PirB is able to improve axonal regeneration following HI damage.
Title: PirB restricts neuronal regeneration in developing rat brain following hypoxia-ischemia.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables inhibitory MHC class I receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response-regulating signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neutrophil immunoglobulin-like receptor 1

Names: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; paired Ig-like receptor B; type 1 one-pass transmembrane Ig-like receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.