Akp3 alkaline phosphatase 3, intestine, not Mn requiring [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akp3provided by RGD
Official Full Name: alkaline phosphatase 3, intestine, not Mn requiringprovided by RGD
Primary source: RGD:621650
See related: EnsemblRapid:ENSRNOG00000058652 AllianceGenome:RGD:621650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Alpi2; IAP-2; IAP-II
Summary: Enables alkaline phosphatase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in response to nutrient levels. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 6.7), Testes (RPKM 3.3) and 1 other tissue See more
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Genomic context

Location:: 9q35

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (95252581..95256616)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87804680..87808715)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (94228960..94232001)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data are consistent with the presence of a triad of zinc atoms at the active site of rat intestinal alkaline phosphatase isozymes rIAP-I, but not rIAP-II or human placental alkaline phosphatase.
Title: Characterization of structural and catalytic differences in rat intestinal alkaline phosphatase isozymes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intestinal-type alkaline phosphatase 2

Names: Intestinal alkaline phosphatase 2; Intestinal alkaline phosphatase II; intestinal alkaline phosphatase-II (IAP-II); putative alkaline phosphatase

NP_073171.2

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022680.2 → NP_073171.2 intestinal-type alkaline phosphatase 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A0G2JZL2, A6JWK7, Q9JKS8

Related

ENSRNOP00000071091.1, ENSRNOT00000080897.3

Conserved Domains (1) summary

pfam00245
Location:52 → 486

Alk_phosphatase; Alkaline phosphatase