Tmem127 transmembrane protein 127 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem127provided by RGD
Official Full Name: transmembrane protein 127provided by RGD
Primary source: RGD:1309744
See related: EnsemblRapid:ENSRNOG00000088819 AllianceGenome:RGD:1309744
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309744
Summary: Predicted to enable small GTPase binding activity. Predicted to be involved in negative regulation of TOR signaling and negative regulation of cell population proliferation. Predicted to act upstream of or within endosome organization. Predicted to be located in early endosome and plasma membrane. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in pheochromocytoma. Orthologous to human TMEM127 (transmembrane protein 127). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 194.6), Lung (RPKM 167.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (134919416..134932210)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (114466095..114478894)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (119677575..119690371)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI317350 (e-PCR)
- UniSTS:159020

RH134539 (e-PCR)
- UniSTS:217819

RH131467 (e-PCR)
- UniSTS:214750

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within endosome organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of TOR signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.