U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stap2 signal transducing adaptor family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363334, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Stap2provided by RGD
    Official Full Name
    signal transducing adaptor family member 2provided by RGD
    Primary source
    RGD:1566020
    See related
    EnsemblRapid:ENSRNOG00000047306 AllianceGenome:RGD:1566020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be located in plasma membrane. Orthologous to human STAP2 (signal transducing adaptor family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 137.0), Lung (RPKM 58.6) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Stap2 in Genome Data Viewer
    Location:
    9q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (915546..924604, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (828369..838648, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (11064605..11070138)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene src homology 2 domain-containing transforming protein D Neighboring gene fibronectin type III and SPRY domain containing 1 Neighboring gene MPN domain containing Neighboring gene SH3 domain containing GRB2 like 1, endophilin A2 Neighboring gene chromatin assembly factor 1 subunit A

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. Minoguchi M, et al. J Biol Chem, 2003 Mar 28. PMID 12540842
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC108972

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    signal-transducing adaptor protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025026.2 → NP_001020197.1  signal-transducing adaptor protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001020197.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887, Q5BK28
      Related
      ENSRNOP00000065679.2, ENSRNOT00000075121.4
      Conserved Domains (2) summary
      cd10404
      Location:151 → 247
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:9 → 135
      PH-like; Pleckstrin homology-like domain

    2. NM_001432963.1 → NP_001419892.1  signal-transducing adaptor protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887

    3. NM_001432964.1 → NP_001419893.1  signal-transducing adaptor protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887

    4. NM_001432965.1 → NP_001419894.1  signal-transducing adaptor protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887

    5. NM_001432966.1 → NP_001419895.1  signal-transducing adaptor protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887

    6. NM_001432967.1 → NP_001419896.1  signal-transducing adaptor protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      M0R887

    7. NM_001432968.1 → NP_001419897.1  signal-transducing adaptor protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    8. NM_001432969.1 → NP_001419898.1  signal-transducing adaptor protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      915546..924604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083945.2 → XP_038939873.1  signal-transducing adaptor protein 2 isoform X4

      UniProtKB/TrEMBL
      M0R887
      Conserved Domains (2) summary
      cd10404
      Location:88 → 184
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:11 → 72
      PH-like; Pleckstrin homology-like domain

    2. XM_063267487.1 → XP_063123557.1  signal-transducing adaptor protein 2 isoform X8

    3. XM_063267484.1 → XP_063123554.1  signal-transducing adaptor protein 2 isoform X5

    4. XM_039083944.2 → XP_038939872.1  signal-transducing adaptor protein 2 isoform X2

      Related
      ENSRNOP00000111439.1, ENSRNOT00000167203.1
      Conserved Domains (2) summary
      cd10404
      Location:112 → 208
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:11 → 96
      PH-like; Pleckstrin homology-like domain

    5. XM_063267485.1 → XP_063123555.1  signal-transducing adaptor protein 2 isoform X6

    6. XM_063267483.1 → XP_063123553.1  signal-transducing adaptor protein 2 isoform X3

    7. XM_039083943.2 → XP_038939871.1  signal-transducing adaptor protein 2 isoform X1

      Related
      ENSRNOP00000078687.2, ENSRNOT00000101244.2
      Conserved Domains (2) summary
      cd10404
      Location:153 → 249
      SH2_STAP2; Src homology 2 domain found in Signal-transducing adaptor protein 2 (STAP2)
      cl17171
      Location:11 → 137
      PH-like; Pleckstrin homology-like domain

    8. XM_063267486.1 → XP_063123556.1  signal-transducing adaptor protein 2 isoform X7

      UniProtKB/TrEMBL
      A6KR17

    9. XM_063267488.1 → XP_063123558.1  signal-transducing adaptor protein 2 isoform X9

    10. XM_063267489.1 → XP_063123559.1  signal-transducing adaptor protein 2 isoform X10

    RNA

    1. XR_010054617.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools