Rnf169 ring finger protein 169 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf169provided by RGD
Official Full Name: ring finger protein 169provided by RGD
Primary source: RGD:1583288
See related: EnsemblRapid:ENSRNOG00000026408 AllianceGenome:RGD:1583288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable modification-dependent protein binding activity; nucleosome binding activity; and ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair via homologous recombination and negative regulation of double-strand break repair. Predicted to be located in cytosol; nuclear body; and nucleolus. Predicted to be active in nucleus and site of double-strand break. Orthologous to human RNF169 (ring finger protein 169). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 103.6), Spleen (RPKM 68.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163662582..163724154, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (154250462..154311867, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164917069..164978061, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF169; ring finger protein 169

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432557.1 → NP_001419486.1 ring finger protein 169

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1LV79

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

163662582..163724154 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001061888.8 → XP_001061888.3 E3 ubiquitin-protein ligase RNF169 isoform X1

Related

ENSRNOP00000036826.4, ENSRNOT00000029629.6

Conserved Domains (1) summary

cd16551
Location:60 → 96

RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
XM_017590193.3 → XP_017445682.1 E3 ubiquitin-protein ligase RNF169 isoform X2
XM_006229823.5 → XP_006229885.1 E3 ubiquitin-protein ligase RNF169 isoform X3

See identical proteins and their annotated locations for XP_006229885.1

UniProtKB/TrEMBL

A6I6L0

Conserved Domains (1) summary

cl23845
Location:44 → 90

DUF2312; Uncharacterized protein conserved in bacteria (DUF2312)