Nol12 nucleolar protein 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nol12provided by RGD
Official Full Name: nucleolar protein 12provided by RGD
Primary source: RGD:1305327
See related: EnsemblRapid:ENSRNOG00000010209 AllianceGenome:RGD:1305327
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nop25; RGD1305327
Summary: Enables rRNA binding activity and single-stranded DNA binding activity. Located in nucleolus. Orthologous to human NOL12 (nucleolar protein 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 16.2), Thymus (RPKM 14.7) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 7q34

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (112373749..112379362)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (110493294..110498908)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (120161238..120166852)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that the nucleolar targeting sequence might play an important role in the binding of Nop25 to RNA molecules and that the RNA binding of Nop25 might be essential for the nucleolar localization of Nop25.
Title: Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables rRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables rRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: nucleolar protein 12

Names: 25 kDa nucleolar protein; nucleolar protein, 25 kDa

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012747.2 → NP_001012765.1 nucleolar protein 12

See identical proteins and their annotated locations for NP_001012765.1

Status: PROVISIONAL

Source sequence(s)

BC103643

UniProtKB/Swiss-Prot

Q5D1Z3

UniProtKB/TrEMBL

A6HSN5

Conserved Domains (1) summary

pfam09805
Location:20 → 67

Nop25; Nucleolar protein 12 (25kDa)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

112373749..112379362

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263916.1 → XP_063119986.1 nucleolar protein 12 isoform X2
XM_006242007.4 → XP_006242069.1 nucleolar protein 12 isoform X1

Related

ENSRNOP00000013764.4, ENSRNOT00000013764.8

Conserved Domains (1) summary

pfam09805
Location:67 → 105

Nop25; Nucleolar protein 12 (25kDa)