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    Mbtd1 mbt domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mbtd1provided by RGD
    Official Full Name
    mbt domain containing 1provided by RGD
    Primary source
    RGD:1592427
    See related
    EnsemblRapid:ENSRNOG00000049988 AllianceGenome:RGD:1592427
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NuA4 histone acetyltransferase complex binding activity; chromatin binding activity; and methylated histone binding activity. Predicted to be involved in double-strand break repair via homologous recombination; regulation of cell cycle; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within embryonic skeletal system development. Predicted to be located in membrane. Predicted to be part of NuA4 histone acetyltransferase complex and nucleosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human MBTD1 (mbt domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 100.2), Kidney (RPKM 77.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mbtd1 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (79336041..79392315)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (78839140..78895413)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (81588233..81645532)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene thymosin, beta 10 like 2 Neighboring gene uncharacterized LOC120095281 Neighboring gene UTP18 small subunit processome component Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation. Honda H, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21252303, Free PMC Article
    2. Structural studies of a four-MBT repeat protein MBTD1. Eryilmaz J, et al. PLoS One, 2009 Oct 20. PMID 19841675, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NuA4 histone acetyltransferase complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MBT domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398942.1 → NP_001385871.1  MBT domain-containing protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I5Y128, A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:471 → 563
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      79336041..79392315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087681.2 → XP_038943609.1  MBT domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    2. XM_063269849.1 → XP_063125919.1  MBT domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Related
      ENSRNOP00000077010.2, ENSRNOT00000109861.2

    3. XM_063269851.1 → XP_063125921.1  MBT domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNG7, A0A8I6AAP7

    4. XM_039087697.2 → XP_038943625.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    5. XM_039087690.2 → XP_038943618.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    6. XM_039087699.2 → XP_038943627.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    7. XM_039087696.1 → XP_038943624.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    8. XM_039087701.1 → XP_038943629.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    9. XM_063269854.1 → XP_063125924.1  MBT domain-containing protein 1 isoform X11

      UniProtKB/TrEMBL
      A0A8I5Y128, A0A8I5ZNG7
      Related
      ENSRNOP00000079891.1, ENSRNOT00000114021.2

    10. XM_039087684.1 → XP_038943612.1  MBT domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    11. XM_063269852.1 → XP_063125922.1  MBT domain-containing protein 1 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZNG7, A0A8I6AAP7

    12. XM_063269853.1 → XP_063125923.1  MBT domain-containing protein 1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Related
      ENSRNOP00000066215.4, ENSRNOT00000072783.5

    13. XM_039087687.2 → XP_038943615.1  MBT domain-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:492 → 584
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    14. XM_039087680.2 → XP_038943608.1  MBT domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    15. XM_039087688.2 → XP_038943616.1  MBT domain-containing protein 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:490 → 582
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    16. XM_039087693.2 → XP_038943621.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    17. XM_039087689.2 → XP_038943617.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    18. XM_039087694.2 → XP_038943622.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    19. XM_039087683.2 → XP_038943611.1  MBT domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    20. XM_039087695.2 → XP_038943623.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    21. XM_039087685.2 → XP_038943613.1  MBT domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:494 → 586
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    22. XM_039087708.2 → XP_038943636.1  MBT domain-containing protein 1 isoform X12

      UniProtKB/TrEMBL
      M0R9N9
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    23. XM_039087705.2 → XP_038943633.1  MBT domain-containing protein 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:490 → 582
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    24. XM_039087700.2 → XP_038943628.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    25. XM_039087682.2 → XP_038943610.1  MBT domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:495 → 587
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    26. XM_039087691.2 → XP_038943619.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    27. XM_039087692.2 → XP_038943620.1  MBT domain-containing protein 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Conserved Domains (1) summary
      smart00561
      Location:473 → 565
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

    28. XM_063269846.1 → XP_063125916.1  MBT domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZNG7
      Related
      ENSRNOP00000089607.2, ENSRNOT00000113570.2

    29. XM_063269850.1 → XP_063125920.1  MBT domain-containing protein 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZNG7

    30. XM_063269856.1 → XP_063125926.1  MBT domain-containing protein 1 isoform X13

    31. XM_039087710.1 → XP_038943638.1  MBT domain-containing protein 1 isoform X13

      Conserved Domains (2) summary
      smart00561
      Location:304 → 396
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      cl17705
      Location:10 → 81
      MBT; mbt repeat
    Nucleotide Protein Strain
    Heading Accession and Version

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