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    Tnks1bp1 tankyrase 1 binding protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tnks1bp1provided by RGD
    Official Full Name
    tankyrase 1 binding protein 1provided by RGD
    Primary source
    RGD:1312021
    See related
    EnsemblRapid:ENSRNOG00000009195 AllianceGenome:RGD:1312021
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ankyrin repeat binding activity and enzyme binding activity. Predicted to be involved in cellular response to ionizing radiation; double-strand break repair; and positive regulation of protein phosphorylation. Predicted to be located in several cellular components, including adherens junction; heterochromatin; and plasma membrane. Predicted to be part of CCR4-NOT complex. Predicted to be active in nucleus. Orthologous to human TNKS1BP1 (tankyrase 1 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 243.4), Adrenal (RPKM 105.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tnks1bp1 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90542006..90566720)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (70135335..70160071)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72458520..72483206)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene purinergic receptor P2X 3 Neighboring gene structure specific recognition protein 1 Neighboring gene apelin receptor Neighboring gene leucine rich repeat containing 55

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182). Seimiya H, et al. J Biol Chem, 2002 Apr 19. PMID 11854288
    2. TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1. Zou LH, et al. Oncotarget, 2015 Mar 30. PMID 25749521, Free PMC Article
    3. Human Ccr4-Not complexes contain variable deadenylase subunits. Lau NC, et al. Biochem J, 2009 Aug 27. PMID 19558367
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ankyrin repeat binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to ionizing radiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    182 kDa tankyrase-1-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429862.1 → NP_001416791.1  182 kDa tankyrase-1-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZF26

    2. NM_001429863.1 → NP_001416792.1  182 kDa tankyrase-1-binding protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D3ZF26

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      90542006..90566720
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006234486.5 → XP_006234548.1  182 kDa tankyrase-1-binding protein isoform X1

      Related
      ENSRNOP00000012209.4, ENSRNOT00000012209.9
      Conserved Domains (1) summary
      pfam15327
      Location:1533 → 1697
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    2. XM_017592170.3 → XP_017447659.1  182 kDa tankyrase-1-binding protein isoform X1

      UniProtKB/TrEMBL
      D3ZF26
      Conserved Domains (1) summary
      pfam15327
      Location:1533 → 1697
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    3. XM_006234485.5 → XP_006234547.1  182 kDa tankyrase-1-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006234547.1

      UniProtKB/TrEMBL
      D3ZF26
      Conserved Domains (1) summary
      pfam15327
      Location:1533 → 1697
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    4. XM_006234484.5 → XP_006234546.1  182 kDa tankyrase-1-binding protein isoform X1

      Conserved Domains (1) summary
      pfam15327
      Location:1533 → 1697
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain

    5. XM_039106449.2 → XP_038962377.1  182 kDa tankyrase-1-binding protein isoform X2

      UniProtKB/TrEMBL
      A6HMT3
      Conserved Domains (1) summary
      pfam15327
      Location:928 → 1091
      Tankyrase_bdg_C; Tankyrase binding protein C terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

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